Arsenic trioxide induces innate immune response and inflammatory response in chicken liver via cGAS-STING/NF-κB pathway.

Autor: Pan H; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: 20222029013@stu.scau.edu.cn., Zhou L; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: zzzzlm@stu.scau.edu.cn., Zou J; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: zoujunbo@stu.scau.edu.cn., Sun J; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: sjp0101@stu.scau.edu.cn., You Y; College of Life Science, Yantai University, Yantai 264005, Shandong Province, China. Electronic address: youyanli@ytu.edu.cn., Zhong G; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: zgl1216@stu.scau.edu.cn., Liao J; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: liaojz@scau.edu.cn., Zhang H; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: hz236@scau.edu.cn., Tang Z; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: tangzx@scau.edu.cn., Hu L; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: hulianmei@scau.edu.cn.
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2024 Dec; Vol. 286, pp. 110017. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.cbpc.2024.110017
Abstrakt: Arsenic is a toxic metal-like element widely used in the pesticide, preservative and semiconductor industries. However, accumulation of arsenic through the food chain can cause serious damage to animal and human health. However, the toxic mechanism of arsenic-induced hepatotoxicity in chickens is not clear, and the present study aimed to investigate the potential role of cGAS-STING and NF-κB pathways on inflammatory injury in chicken liver. In this study, 75 white-feathered broilers were divided into a control group, a low-dose arsenic group (4 mg/kg) and a high-dose arsenic group (8 mg/kg) to investigate the toxic effects of arsenic on chicken liver. In this study, we found that pathological changes such as inflammatory cell infiltration and vesicular degeneration occurred in the liver when exposed to ATO. Crucially, exposure to ATO triggered the cGAS-STING pathway and markedly raised the levels of mRNA and protein expression of cGAS, STING, TBK1, and IRF7. The type I interferon response was also triggered. Simultaneously, STING induced the activation of the conventional NF-κB signaling pathway and stimulated the expression of genes associated with inflammation, such as IL-6, TNF-α and IL-1β. In summary, the induction of inflammatory responses via cGAS-STING and NF-κB signaling pathways under high ATO exposure provides new ideas for further studies on the toxicological mechanisms of arsenic.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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