Assessment of conjunctival autograft reperfusion after pterygium surgery by optical coherence tomography angiography (OCT-A).

Autor: Masoumi A; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran., Esfandiari A; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran., Khalili A; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran., Latifi G; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran., Ghanbari H; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: hamidghanbari72@yahoo.com., Jafari B; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran., Montazeriani Z; Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences and Research Center for Science and Technology in Medicine, Tehran, Iran., Rahimi M; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran., Ghafarian S; Department of Ophthalmology, Farabi Eye Hospital, School of medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Ghafarians@gmail.com.
Jazyk: angličtina
Zdroj: Microvascular research [Microvasc Res] 2025 Jan; Vol. 157, pp. 104734. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1016/j.mvr.2024.104734
Abstrakt: Purpose: To investigate the healing process of conjunctival autografts (CAG) following pterygium surgery using optical coherence tomography angiography (OCTA).
Methods: Twenty-one eyes of 21 patients diagnosed with pterygium underwent pterygium excision with CAG without using Mitomycin-C. Over a 12-week follow-up period, changes in vascular density (VD), vascular density index (VDI), and vascular length density (VLD) were assessed at two distinct depths: superficial (<200 μm) and deep (>200 μm) using OCTA. Additionally, the revascularization rate and pattern were evaluated.
Results: During the first week, the CAG was edematous and no sign of neovascularization was observed. In 4th week edema decreased and early signs of vascular formation appeared. In the 12th week, the deep vasculature demonstrated a greater density of interconnectivity compared to the superficial layers. VD and VLD significantly increased during the follow-up period (P < 0.05). The CAG blood flow signals exhibited a chaotic pattern, deviating from the expected centrifugal vascular pattern in the surrounding normal conjunctiva.
Conclusion: OCTA imaging emerges as a reliable tool for the assessment of CAG vascularization, improving the monitoring of the healing process in the postoperative period. The evaluation of CAG revascularization patterns appears to be promising biomarkers that can predict the potential future recurrence.
Competing Interests: Declaration of competing interest All authors certify that they have no affiliation with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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