Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry.

Autor:	Schweiger V; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland; Department of Cardiology, Deutsches Herzzentrum der Charité, Angiology and Intensive Care Medicine, Berlin, Germany., Cammann VL; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland., Crisci G; Department of Translational Medical Sciences, 'Federico II' University, Naples, Italy., Gilhofer T; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland., Schlenker R; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland., Niederseer D; Hochgebirgsklinik, Medicine Campus Davos, Davos, Switzerland; Christine Kühne Center for Allergy Research and Education (CK-CARE), Medicine Campus Davos, Davos, Switzerland; Center of Translational and Experimental Cardiology, University Hospital Zurich, Zurich Switzerland., Chen S; Cardioangiologisches Centrum Bethanien (CCB), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany., Ebrahimi R; Cardioangiologisches Centrum Bethanien (CCB), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany; Heart Clinic Pratteln, Zentrum für Kardiologie, Pratteln, Switzerland., Wenzl F; Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland., Würdinger M; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland., Citro R; Department of Vascular Physiopathology, IRCCS Neuromed, Pozzilli, Italy; Division of Clinical Cardiology Research Responsible Hospital, Department of Medicine and Health Science, University of Molise, Campobasso, Italy., Vecchione C; Department of Vascular Physiopathology, IRCCS Neuromed, Pozzilli, Italy; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy., Gili S; Centro cardiologico Monzino, IRCCS, Milan, Italy., Neuhaus M; Department of Cardiology, Kantonsspital Frauenfeld, Frauenfeld, Switzerland., Franke J; Department of Cardiology, Heidelberg University Hospital, Heidelberg, Germany., Meder B; Department of Cardiology, Heidelberg University Hospital, Heidelberg, Germany., Jaguszewski M; First Department of Cardiology, Medical University of Gdansk, Gdansk, Poland., Noutsias M; Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Knorr M; Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., Jansen T; Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., D'Ascenzo F; Division of Cardiology, Department of Medical Sciences, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy., Dichtl W; University Hospital for Internal Medicine III (Cardiology and Angiology), Medical University Innsbruck, Innsbruck, Austria., von Lewinski D; Division of Cardiology, Medical University of Graz, Graz, Austria., Burgdorf C; Heart and Vascular Centre Bad Bevensen, Bad Bevensen, Germany., Kherad B; Department of Cardiology, Deutsches Herzzentrum der Charité, Angiology and Intensive Care Medicine, Berlin, Germany., Tschöpe C; Department of Cardiology, Deutsches Herzzentrum der Charité, Angiology and Intensive Care Medicine, Berlin, Germany., Sarcon A; Section of Cardiac Electrophysiology, Department of Medicine, University of California-San Francisco, San Francisco, California, USA., Shinbane J; University of Southern California, Keck School of Medicine, Los Angeles, California, USA., Rajan L; TJ Health Partners Heart and Vascular, Glasgow, Kentucky, USA., Michels G; Klinik für Akut-und Notfallmedizin, St Antonius Hospital gGmbH, Akademisches Lehrkrankenhaus der RWTH Aachen, Eschweiler, Germany., Pfister R; Department of Cardiology, Deutsches Herzzentrum der Charité, Angiology and Intensive Care Medicine, Berlin, Germany., Cuneo A; Krankenhaus 'Maria Hilf' Medizinische Klinik, Stadtlohn, Germany., Jacobshagen C; Clinic for Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany; Vincentius-Diakonissen Hospital, Karlsruhe, Germany., Karakas M; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Pott A; Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany., Meyer P; Service de cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Roffi M; Service de cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Banning A; Department of Cardiology, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom., Wolfrum M; Department of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland., Cuculi F; Department of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland., Kobza R; Department of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland., Fischer TA; Department of Cardiology, Kantonsspital Winterthur, Winterthur, Switzerland., Vasankari T; Heart Center, Turku University Hospital and University of Turku, Turku, Finland., Airaksinen KEJ; Heart Center, Turku University Hospital and University of Turku, Turku, Finland., Napp LC; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Dworakowski R; Department of Cardiology, King's College Hospital, London, United Kingdom., MacCarthy P; Department of Cardiology, King's College Hospital, London, United Kingdom., Kaiser C; Department of Cardiology, University Hospital Basel, Basel, Switzerland., Osswald S; Department of Cardiology, University Hospital Basel, Basel, Switzerland., Galiuto L; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy., Chan C; Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand., Bridgman P; Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand., Beug D; Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Delmas C; Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, France., Lairez O; Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, France., Gilyarova E; Intensive coronary care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia., Shilova A; Intensive coronary care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia., Gilyarov M; Intensive coronary care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia., El-Battrawy I; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg, Mannheim, Germany; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim, Mannheim, Germany., Akin I; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg, Mannheim, Germany; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim, Mannheim, Germany., Poledniková K; Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady, Prague, Czech Republic., Toušek P; Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady, Prague, Czech Republic., Winchester DE; Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA., Massoomi M; Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA., Galuszka J; Department of Internal Medicine I-Cardiology, University Hospital Olomouc, Olomouc, Czech Republic., Ukena C; Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany., Poglajen G; Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana, Ljubljana, Slovenia., Carrilho-Ferreira P; Santa Maria University Hospital, CHULN, Center of Cardiology of the University of Lisbon, Lisbon School of Medicine, Lisbon Academic Medical Center, Lisboa, Portugal., Hauck C; Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany., Paolini C; Local Health Unit no.8, Cardiology Unit, Arzignano, Vicenza, Italy., Bilato C; Local Health Unit no.8, Cardiology Unit, Arzignano, Vicenza, Italy., Kobayashi Y; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan., Kato K; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan., Ishibashi I; Department of Cardiology, Chiba Emergency Medical Center, Chiba, Japan., Himi T; Division of Cardiology, Kimitsu Central Hospital, Kisarazu, Japan., Din J; Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, United Kingdom., Al-Shammari A; Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, United Kingdom., Prasad A; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA., Rihal CS; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA., Liu K; Division of Cardiology, Heart and Vascular Center, University of Iowa, Iowa City, Iowa, USA., Schulze PC; Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany., Bianco M; Division of Cardiology, A.O.U San Luigi Gonzaga, Orbassano, Turin, Italy., Jörg L; Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland., Rickli H; Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland., Pestana G; Department of Cardiology, Centro Hospitalar Universitário de São João, E.P.E., Porto, Portugal., Nguyen TH; Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia, Australia., Böhm M; Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany., Maier LS; Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany., Pinto FJ; Santa Maria University Hospital, CHULN, Center of Cardiology of the University of Lisbon, Lisbon School of Medicine, Lisbon Academic Medical Center, Lisboa, Portugal., Widimský P; Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady, Prague, Czech Republic., Felix SB; Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Braun-Dullaeus RC; Department of Internal Medicine, Cardiology and Angiology, Magdeburg University, Magdeburg, Germany., Rottbauer W; Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany., Hasenfuß G; Clinic for Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany., Pieske BM; Deutsches Herzzentrum der Charité, Department of Cardiology (CVK) and German Centre for Cardiovascular Research (DZHK)-Partner Site Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH) at Charité-Center for Regenerative Therapies, Universitätsmedizin Berlin, Berlin, Germany., Schunkert H; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Budnik M; Department of Cardiology, Medical University of Warsaw, Warsaw, Poland., Opolski G; Department of Cardiology, Medical University of Warsaw, Warsaw, Poland., Thiele H; Heart Center Leipzig-At Leipzig University, Department of Internal Medicine/Cardiology, Leipzig Heart Science, Leipzig, Germany., Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Horowitz JD; Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia, Australia., Di Mario C; Structural Interventional Cardiology, Careggi University Hospital, Florence, Italy., Kong W; Department of Cardiology, National University Heart Centre, Singapore., Dalakoti M; Department of Cardiology, National University Heart Centre, Singapore., Imori Y; Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan., Münzel T; Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., Liberale L; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy., Montecucco F; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa-Italian Cardiovascular Network, Genoa, Italy., Bax JJ; Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands., Crea F; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy., Ruschitzka F; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland., Lüscher TF; Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland; Royal Brompton and Harefield Hospitals Trust and Imperial College, London, United Kingdom., Ghadri JR; University Heart Center, Department of Cardiology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland., Bossone E; Department of Public Health, University 'Federico II' of Naples, Naples, Italy., Templin C; Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland; Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Swiss CardioVascularClinic, Private Hospital Bethanien, Zurich, Switzerland. Electronic address: christian.templin@usz.ch., Di Vece D; Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.
Jazyk:	angličtina
Zdroj:	Journal of the American College of Cardiology [J Am Coll Cardiol] 2024 Sep 24; Vol. 84 (13), pp. 1178-1189. Date of Electronic Publication: 2024 Sep 01.
DOI:	10.1016/j.jacc.2024.05.076
Abstrakt:	Background: The perception of takotsubo syndrome (TTS) has evolved significantly over the years, primarily driven by increased recognition of acute complications and mortality. Objectives: This study aimed to explore temporal trends in demographic patterns, risk factors, clinical presentations, and outcomes in patients with TTS. Methods: Patients diagnosed with TTS between 2004 and 2021 were enrolled from the InterTAK (International Takotsubo) registry. To assess temporal trends, patients were divided into 6 groups, each corresponding to a 3-year interval within the study period. Results: Overall, 3,957 patients were included in the study. There was a significant demographic transition, with the proportion of male patients rising from 10% to 15% (P = 0.003). Although apical TTS remained the most common form, the diagnosis of midventricular TTS increased from 18% to 28% (P = 0.018). The prevalence of physical triggers increased from 39% to 58% over the years (P < 0.001). There was a significant increase in 60-day mortality over the years (P < 0.001). However, a landmark analysis excluding patients who died within the first 60 days showed no differences in 1-year mortality (P = 0.150). Conclusions: This study of temporal trends in TTS highlights a transition in patients demographic with a growing prevalence among men, increasing recognition of midventricular TTS type, and increased short-term mortality and rates of cardiogenic shock in recent years. This transition aligns with the rising prevalence of physical triggers, as expression of increased recognition of TTS in association with acute comorbidities. Competing Interests: Funding Support and Author Disclosures Dr Templin has received institutional grants from Abbott Vascular, Medtronic, and SMT; and has received consulting grants from Biotronik, Microport, and Innova. Dr Airaksinen has received grants or has contracts with the Finnish Foundation for Cardiovascular Research; and has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Bayer, Pfizer, Boehringer Ingelheim, and AstraZeneca. Dr Bauersachs has received grants from or has contracts with Abiomed, CVRx, Norgine, Roche, and Zoll; holds patents PCT/EP2007/008772 and PCT/EP2009/051986 for microRNA and downstream targets for diagnostics and therapeutic purposes; has received consulting fees from Amgen, AstraZeneca, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Cardior, Corvia, CVRx, Edwards, Norgine, Novartis, Pfizer, Roche, and Vifor; and has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Amgen, AstraZeneca, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Cardior, CVRx, Norgine, Novartis, Pfizer, and Vifor. Dr Boehm has received grants from or has contracts with Deutsche Forschungsgemeinschaft research support (DFG, SFB-TTR 219, S-01); has received speaker honoraria from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Cytokinetics, Medtronic, Novartis, Servier, and Vifor; and is on the advisory board of Amgen, Bayer, Boehringer Ingelheim, Cytokinetics, Medtronic, Novartis, Pfizer, ReCor, Servier, and Vifor. Dr Ferreira has received payments for lectures, presentations, speakers bureaus, manuscript writing, or educational events from A Menarini, Medinfar, Bayer, AstraZeneca, Biotronik, and Medtronic; and has received payments for participation on a Data Safety Monitoring Board or Advisory Board from Medtronic. Dr Dichtl has received consulting fees from Reata. Dr Kaiser has received consulting fees from the Swiss Federal Office of Public Health; and has received support for attending meetings and/or travel from Medtronic, Abbott, and Europa Organization. Dr Kobza has received institutional grants on behalf of the Luzerner Kantonsspital from Biosense Webster, Boston Scientific, Biotronik, Medtronik, and Sis-Medical; and has received consulting fees from Biosense Webster, Biotronik, and Medtronic. Dr Koenig has received grants and provision of reagents to the institution from Singulex, Dr.Beckmann Pharma, Abbott, and Roche Diagnostics; has received consulting fees from AstraZeneca, Novartis, Amgen, Pfizer, The Medicines Company, DalCor Pharmaceuticals, Kowa, Corvidia Therapeutics, OMEICOS, Daiichi-Sankyo, Novo Nordisk, New Amsterdam Pharma, TenSixteen Bio, Esperion, and Genentech; and has received lecture fees from Bristol Myers Squibb, Novartis, Amgen, Berlin-Chemie, Sanofi, and AstraZeneca. Dr Lüscher has received research or educational grants to the institution from Abbott, Amgen, AstraZeneca, Boehringer Ingelheim, Daiichi-Sankyo, Novartis, Novo Nordisk, Sanofi, and Vifor; is the president elect of the European Society of Cardiology; is chairman of the research committee of the Swiss Heart Foundation; is President of the Board of the Zurich Heart House; and is Trustee of the London Heart House. Dr Karakas has received grants or has contracts with Vifor Pharma and Daiichi-Sankyo; has received consulting fees or payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Vifor, Pharmacosmos, and Sphingotec; and has received equipment, materials, drugs, medical writing, gifts or other services from Sphingotec and Vifor Pharma. Dr Niederseer has received consulting fees from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi-Sankyo, Gerson Lehmann Group (GLG) Consulting, Novo Nordisk, Pfizer and Zoll; has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi-Sankyo, Novartis, Novo Nordisk, and Pfizer; and has received support for attending meetings and/or travel from Abbott, Amgen, Bayer, and Novo Nordisk. Dr Roffi has received institutional research grants from Boston Scientific, Cordis, Terumo, Biotronik, and Medtronic. Dr Ruschitzka has not received personal payments by pharmaceutical companies or device manufacturers in the last 3 years; the Department of Cardiology (University Hospital of Zurich/University of Zurich), however, reports research, educational, and/or travel grants from Abbott, Abiomed, Alexion, Amgen, AstraZeneca, At the Limits Ltd, Bayer, Berlin Heart, B. Braun, Biosense Webster, Biosensors Europe AG, Biotronik, Bristol Myers Squibb, Boehringer Ingelheim, Boston Scientific, Bracco, Cardinal Health Switzerland, Concept Medical, Corteria, CSL, Daiichi-Sankyo, Diatools AG, Edwards Lifesciences, Guidant Europe NV, Hamilton Health Sciences, IHF, Innosuisse, Johnson/Johnson, Kaneka Corporation, Kantar, Kiniksa, Labormedizinisches Zentrum, MedAlliance, Medical Education Global Solutions, Medtronic, MicroPort, MSD, Mundipharma Medical Company, Novartis, Novo Nordisk, Orion, Pfizer, Quintiles Switzerland Sarl, RecorMedical, Roche Diagnostics, Roche Pharma, Sahajanand IN, Sanofi, Sarstedt AG, Servier, SIS Medical, Sorin CRM SAS, SSS International Clinical Research, Stromal, Terumo Deutschland, Trama Solutions, V-Wave, Vascular Medical, Vifor, Wissens Plus, and ZOLL. Prof Ruschitzka has not received personal payments by pharmaceutical companies or device manufacturers in the last 3 years; remuneration for the time spent in the following consulting activities were made directly to the University of Zurich and do not impact on his personal remuneration: AstraZeneca (IMC), Bayer, Boehringer Ingelheim, Citi Research, Klub Class, Novo Nordisk, Radcliffe Group, Stiftung Pfizer Forschungspreis, and Vifor; remuneration for the following lectures were made directly to the University of Zurich and do not impact on his personal remuneration: Abbott, Amgen, AstraZeneca (A+ Science AB), Bayer (At the Limits), Boehringer Ingelheim, Boston Scientific (CCE Services), Brigham and Women’s Hospital Boston, C.T.I GmbH, FomF, Hôpitaux Universitaires des Genève (GECORE), Luzerner Kantonsspital, Sanofi-Aventis, Servier, Medcon, Medscape (WebMD), Medtronic, Medworld, Novartis, Roche, Ruwag, Swiss Heart Failure Academy, The Hong Kong Heart Failure Society, Trama Solutions SL, Inselspital Bern, Charité–Universitätsmedizin Berlin (Medical Education Global Solutions), Romanian Society of Cardiology, ÖKG Österreichische Gesellschaft für Kardiologie, and Zoll; has received support for attending meetings and/or travel from AstraZeneca (IMC/A+ Science AB), Boehringer Ingelheim, Centro Hospitaler de Vila Nova de Gaia, C.T.I. GmbH (Universitätsklinikum Düsseldorf), European Society of Cardiology, Monocle, Novartis, Spektar Putovanja, Austrian Heart Failure Association, and Heart Failure Association of the ESC; remuneration for following Advisory Boards were made directly to the University of Zurich and do not impact on his personal remuneration: Bayer, Roche, IMC/AstraZeneca, and Amgen; and he has received secretarial and administrative support of the HFA for his role as President/Past-President for 2018 to 2020. Dr Schunkert has received consulting fees from Amgen, Daiichi-Sankyo, Merck Sharp and Dohme, AstraZeneca, Bayer, Boehringer Ingelheim, Novartis, and Servier; has received honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events and support for attending meetings and/or travel from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi-Sankyo, Merck Sharp and Dohme, Novartis, Sanofi Aventis, Servier, and Synlab; and has received honoraria for his participation on a Data Safety Monitoring Board or Advisory Board of Boehringer Ingelheim, Daiichi-Sankyo, Novartis, and Amgen. Dr Wolfrum has received consulting fees from NVT/Biosensors as well as payments for lectures, presentations, speakers bureaus, manuscript writing, or educational events from NVT/Biosensors; and has equities in Hi-D Imaging, Winterthur, Switzerland. Dr Crea has received personal fees from Amgen, AstraZeneca, Abbott, Menarini, Chiesi, and Daiichi-Sankyo, outside of the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
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