The molecular basis of the anticancer effect of statins.

Autor: Buccioli G; Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy., Testa C; Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy., Jacchetti E; Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy., Pinoli P; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy., Carelli S; Center of Functional Genomics and Rare Diseases, Buzzi Children's Hospital, Milan, Italy., Ceri S; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy. stefano.ceri@polimi.it., Raimondi MT; Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy. manuela.raimondi@polimi.it.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 31; Vol. 14 (1), pp. 20298. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1038/s41598-024-71240-6
Abstrakt: Statins, widely used cardiovascular drugs that lower cholesterol by inhibiting HMG-CoA reductase, have been increasingly recognized for their potential anticancer properties. This study elucidates the underlying mechanism, revealing that statins exploit Synthetic Lethality, a principle where the co-occurrence of two non-lethal events leads to cell death. Our computational analysis of approximately 37,000 SL pairs identified statins as potential drugs targeting genes involved in SL pairs with metastatic genes. In vitro validation on various cancer cell lines confirmed the anticancer efficacy of statins. This data-driven drug repurposing strategy provides a molecular basis for the anticancer effects of statins, offering translational opportunities in oncology.
(© 2024. The Author(s).)
Databáze: MEDLINE
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