Persistent endocrine-disrupting chemicals and incident uterine leiomyomata: A mixtures analysis.

Autor: Wesselink AK; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America. Electronic address: akw23@bu.edu., Claus Henn B; Department of Environmental Health, Boston University School of Public Health, Boston, MA, United States of America., Fruh V; Department of Environmental Health, Boston University School of Public Health, Boston, MA, United States of America., Geller RJ; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America., Coleman CM; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America., Schildroth S; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America., Sjodin A; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America., Bethea TN; Lombardi Cancer Center, Georgetown University, Washington, DC, United States of America., Noel NL; Department of Obstetrics & Gynecology, Chobanian and Avedisian School of Medicine, Boston University, Boston Medical Center, United States of America., Baird DD; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., Wegienka G; Henry Ford Health, Detroit, MI, United States of America., Wise LA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States of America.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Nov 15; Vol. 951, pp. 175871. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.scitotenv.2024.175871
Abstrakt: Background: Uterine leiomyomata (UL; fibroids) are hormone-dependent neoplasms that can cause significant gynecologic morbidity. Studies have documented associations between concentrations of persistent endocrine-disrupting chemicals (EDCs) and UL incidence; however, few have assessed the effects of EDC mixtures on UL.
Methods: In the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study, participants attended study visits at baseline and approximately every 20 months for up to 10 years; at each visit, they completed questionnaires, provided blood samples, and underwent standardized ultrasound examinations. In baseline plasma samples (n = 1155), we quantified concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides using high-resolution mass spectrometry. We selected nine EDCs detected in >60 % of samples (4 PCBs, 4 PBDEs, and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene (p,p'-DDE)) and conducted probit Bayesian kernel machine regression with hierarchical variable selection to estimate effects of the EDC mixture and individual EDCs on UL incidence, adjusting for potential confounders.
Results: During 10 years of follow-up, 32 % of participants developed ultrasound-detected UL. The EDC mixture was not appreciably associated with the probit of UL (β comparing all EDCs at their 75th vs. 50th percentile:= - 0.01, 95 % credible interval [CrI]: -0.11, 0.10). However, individual EDC concentrations were associated with UL in opposing directions: PCB138/158 was positively associated with UL (β for 25th-to-75th-percentile increase when all other chemicals were set to their 50th percentile = 0.18, 95 % CrI: -0.09, 0.44), whereas PBDE99 and p,p'-DDE were inversely associated with UL (β = -0.06, 95 % CrI: -0.21, 0.10 and β = -0.12, 95 % CrI: -0.34, 0.10, respectively). There was little evidence of interaction between EDCs.
Conclusion: In this prospective ultrasound study, a mixture of persistent EDCs was not appreciably associated with incident UL during 10 years of follow-up, but individual EDCs were associated with UL in opposite directions.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lauren A. Wise reports a consulting relationship with AbbVie Inc., and the Bill & Melinda Gates Foundation. LAW receives in-kind donations for primary data collection in Pregnancy Study Online (PRESTO), including home pregnancy tests (Swiss Precision Diagnostics) and fertility-tracking apps (Kindara.com). All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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