β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.

Autor: Wang R; College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China; The First People's Hospital of Foshan, Foshan, Guangdong province, China., Yang X; College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning Province, China., Wang L; College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China., Wang R; College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China., Zhang W; College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, Liaoning province, China., Ji Y; College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning Province, China., Li Z; Heyou Hospital of Guangdong Province. Electronic address: gdlzy163@126.com., Li H; College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning Province, China. Electronic address: dllihua@dmu.edu.cn., Cui L; The First People's Hospital of Foshan, Foshan, Guangdong province, China. Electronic address: CLX18038863001@163.com.
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 2024 Nov 15; Vol. 983, pp. 176959. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.ejphar.2024.176959
Abstrakt: Aging is an inevitable law of the process of life during which many physiological functions change. Brain aging is an important mechanism in the occurrence and development of degenerative diseases of the central nervous system. β-Hydroxybutyrate (BHBA) is a water-soluble, endogenous small-molecule ketone that can cross the blood-brain barrier and induce neuroprotective effects. This study aimed to investigate the effects of BHBA on D-galactose (D-gal) induced aging in mice and its underlying mechanisms using in vitro and in vivo experiments. These results indicated that D-gal-induced senescence, oxidative stress, and inflammatory responses were inhibited by BHBA, and autophagy was promoted by BHBA. Mechanistically, we explored the role of metastasis-associated antigen-1 (MTA1) in D-gal-induced damaged in HT22 cells using small interfering RNA (siRNA). The results demonstrated that the expression of MTA1 was significantly increased by BHBA, which attenuated D-gal-induced aging, oxidative stress, and inflammatory responses, and promoted autophagy through the upregulation of MTA1. In conclusion, MTA1 may be a novel target for treating aging caused by neurological damage. BHBA improves brain aging by activating the MTA1 pathway.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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