Associations of maternal serum concentration of iron-related indicators with gestational diabetes mellitus in Chinese: A pilot prospective cohort study.

Autor: Chen GD; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China. Electronic address: chgengd@163.com., Li PS; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Zhou ZX; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Pang TT; Department of Medical Records, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Wang HY; Biobank of Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Gou XY; Biobank of Foshan Institute of Fetal Medicine, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Ye SX; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Lin DX; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Fan DZ; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China., Liu ZP; Foshan Institute of Fetal Medicine, Department of Obstetrics, Foshan Women and Children Hospital, Foshan city, Guangdong Province 528000, China; Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong 528000, China.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2024 Dec; Vol. 86, pp. 127514. Date of Electronic Publication: 2024 Aug 29.
DOI: 10.1016/j.jtemb.2024.127514
Abstrakt: Background: We aimed to provide a comprehensive understanding of the associations between iron metabolism and gestational diabetes mellitus (GDM) by examining multiple iron-related indicators.
Methods: We conducted a prospective study involving 907 Chinese pregnant women. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of iron-related indicators during the first trimester (≤ 14 weeks of gestation). GDM outcomes were measured through oral glucose tolerance tests (OGTT) conducted between weeks 24 and 28 of gestation.
Results: Subjects with iron-related indicators below the 10th percentile (except for serum iron and soluble transferrin receptor) had a higher risk of GDM compared to normal subjects (10th-90th percentiles). The ORs (95 %CI; p-value) were 1.88 (1.10, 3.20; P=0.020) for ferritin, 1.88 (1.10, 3.19; P=0.020) for hepcidin. Higher levels of ferritin (> 90th percentile) were associated with a higher risk of abnormal fasting blood glucose, while lower levels (< 10th percentile) of ferritin, hepcidin, and transferrin were associated with a higher risk of one-hour postprandial glucose ≥ 8.6 mmol/L in the OGTT.
Conclusions: Lower levels (< 10th percentiles) of several iron-related indicators (ferritin, hepcidin, and transferrin) were associated with a higher risk of GDM and abnormal blood glucose compared to normal subjects.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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