Assessing hip joint-related structure and patient-reported outcomes in people with Marfan syndrome.

Autor: Cochran KE; College of Medicine, University of Kentucky, Lexington, KY, USA., Steele LT; College of Medicine, University of Kentucky, Lexington, KY, USA., Fain AD; Department of Radiology, University of Kentucky, Lexington, KY, USA., Gaffney BMM; Department of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA.; Center for Bioengineering, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.; Department of Veterans Affairs Eastern Colorado Healthcare System, Aurora, CO, USA., McLouth CJ; Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Sheppard MB; Department of Family and Community Medicine, Surgery, and Physiology, University of Kentucky, Lexington, KY, USA.; Saha Aortic Center and Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA., Samaan MA; Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA. michael.samaan@uky.edu.
Jazyk: angličtina
Zdroj: Skeletal radiology [Skeletal Radiol] 2024 Aug 31. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1007/s00256-024-04775-4
Abstrakt: Objective: People with Marfan syndrome (MFS) have clinical symptoms of hip pain, but to date, there is limited knowledge about hip-related structural abnormalities in these patients. Therefore, the purpose of this cross-sectional study was to assess hip-related structural abnormalities and patient-reported outcomes (PRO) in a cohort of patients with MFS compared to healthy controls.
Methods: Nineteen individuals with MFS (17 females, 39.8±11.5 years) and 19 age, sex, and body mass index-matched healthy, asymptomatic individuals (17 females, 36.2±12.5 years) underwent radiographic imaging and unilateral hip MRI. The Scoring Osteoarthritis with MRI (SHOMRI) technique was used to assess hip-related morphological abnormalities between the MFS and control groups. All participants completed the Hip disability and Osteoarthritis Outcome Score (HOOS) to assess hip-related symptoms, pain, and function during activities of daily living (ADL) and quality of life (QOL).
Results: The MFS group exhibited higher lateral center edge angles (p < .001). Despite similar severity of femoral cartilage damage (p = 1.0), the MFS group exhibited a higher severity (p = 0.046) of acetabular cartilage degeneration (1.21±1.08) compared to the controls (0.53±1.02). There were no between-group differences in severity of labral pathology, subchondral cysts, or edema. Individuals with MFS also self-reported significantly lower HOOS symptoms (p = 0.003), pain (p = 0.014), ADL (p = 0.028), and QOL (p = 0.014) sub-scores, indicating worse hip-related PRO in MFS.
Conclusion: Our study results suggest that individuals with MFS exhibit early signs of acetabular cartilage degeneration and poor hip-related clinical outcomes compared to healthy individuals. Future work should investigate the underlying biomechanical mechanisms associated with hip joint degeneration in the MFS population.
(© 2024. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
Databáze: MEDLINE
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