Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.

Autor: Reddy JS; Mayo Clinic Florida, Jacksonville, Florida, USA., Heath L; Sage Bionetworks, Seattle, Washington, USA., Linden AV; Sage Bionetworks, Seattle, Washington, USA., Allen M; Mayo Clinic Florida, Jacksonville, Florida, USA., Lopes KP; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Seifar F; Emory University School of Medicine, Atlanta, Georgia, USA., Wang E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Ma Y; Columbia University Irving Medical Center, New York, New York, USA., Poehlman WL; Sage Bionetworks, Seattle, Washington, USA., Quicksall ZS; Mayo Clinic Florida, Jacksonville, Florida, USA., Runnels A; New York Genome Center, New York, New York, USA., Wang Y; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Duong DM; Emory University School of Medicine, Atlanta, Georgia, USA., Yin L; Emory University School of Medicine, Atlanta, Georgia, USA., Xu K; Emory University School of Medicine, Atlanta, Georgia, USA., Modeste ES; Emory University School of Medicine, Atlanta, Georgia, USA., Shantaraman A; Emory University School of Medicine, Atlanta, Georgia, USA., Dammer EB; Emory University School of Medicine, Atlanta, Georgia, USA., Ping L; Emory University School of Medicine, Atlanta, Georgia, USA., Oatman SR; Mayo Clinic Florida, Jacksonville, Florida, USA., Scanlan J; Sage Bionetworks, Seattle, Washington, USA., Ho C; Mayo Clinic Florida, Jacksonville, Florida, USA., Carrasquillo MM; Mayo Clinic Florida, Jacksonville, Florida, USA., Atik M; Mayo Clinic Florida, Jacksonville, Florida, USA., Yepez G; Mayo Clinic Florida, Jacksonville, Florida, USA., Mitchell AO; Mayo Clinic Florida, Jacksonville, Florida, USA., Nguyen TT; Mayo Clinic Florida, Jacksonville, Florida, USA., Chen X; Mayo Clinic Florida, Jacksonville, Florida, USA., Marquez DX; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; University of Illinois Chicago, Chicago, Illinois, USA., Reddy H; Columbia University Irving Medical Center, New York, New York, USA., Xiao H; Columbia University Irving Medical Center, New York, New York, USA., Seshadri S; The Glen Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, San Antonio, Texas, USA., Mayeux R; Columbia University Irving Medical Center, New York, New York, USA., Prokop S; University of Florida, Gainesville, Florida, USA., Lee EB; Center for Neurodegenerative Disease Brain Bank at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, Arizona, USA., Beach TG; Banner Sun Health Research Institute, Sun City, Arizona, USA., Teich AF; Columbia University Irving Medical Center, New York, New York, USA., Haroutunian V; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Fox EJ; Emory University School of Medicine, Atlanta, Georgia, USA., Gearing M; Emory University School of Medicine, Atlanta, Georgia, USA., Wingo A; Emory University School of Medicine, Atlanta, Georgia, USA., Wingo T; Emory University School of Medicine, Atlanta, Georgia, USA., Lah JJ; Emory University School of Medicine, Atlanta, Georgia, USA., Levey AI; Emory University School of Medicine, Atlanta, Georgia, USA., Dickson DW; Mayo Clinic Florida, Jacksonville, Florida, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., De Jager P; Columbia University Irving Medical Center, New York, New York, USA., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Bennett D; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Seyfried NT; Emory University School of Medicine, Atlanta, Georgia, USA., Greenwood AK; Sage Bionetworks, Seattle, Washington, USA., Ertekin-Taner N; Mayo Clinic Florida, Jacksonville, Florida, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Aug 30. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1002/alz.14208
Abstrakt: Introduction: Multi-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are disproportionately affected by AD.
Methods: To bridge this gap, Accelerating Medicines Partnership in Alzheimer's Disease (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.
Results: We generated multi-omics data and curated and harmonized phenotypic data from BA (n = 306), LA (n = 326), or BA and LA (n = 4) brain donors plus non-Hispanic White (n = 252) and other (n = 20) ethnic groups, to establish a foundational dataset enriched for BA and LA participants. This study describes the data available to the research community, including transcriptome from three brain regions, whole genome sequence, and proteome measures.
Discussion: The inclusion of traditionally underrepresented groups in multi-omics studies is essential to discovering the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.
Highlights: Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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