Cold case: COVID-19-triggered type 1 cryoglobulinemia.

Autor: van Gils LAJL; Meander Medical Center, department of Internal Medicine, Amersfoort, Netherlands. Luukvangils@gmail.com., Corsten MFM; Meander Medical Center, department of Internal Medicine, Amersfoort, Netherlands., Koelman CAC; Meander Medical Center, department of Medical Microbiology and Medical Immunology, Amersfoort, Netherlands., Bosma RJR; Meander Medical Center, department of Internal Medicine, Amersfoort, Netherlands., Fijnheer RR; Meander Medical Center, department of Internal Medicine, Amersfoort, Netherlands., Mulder AHLL; Unilabs, Clinical Laboratory, Enschede, Netherlands., Regelink JCJ; Meander Medical Center, department of Internal Medicine, Amersfoort, Netherlands.
Jazyk: angličtina
Zdroj: Annals of hematology [Ann Hematol] 2024 Oct; Vol. 103 (10), pp. 4305-4308. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1007/s00277-024-05970-y
Abstrakt: A 42-year-old male was referred to the internal medicine department because of renal failure and persistent malaise after a recent SARS-CoV-2 infection. Blood results showed anemia and severe renal insufficiency (hemoglobin of 10.3 g/dL and a creatinine of 2.19 mg/dL). Additional tests revealed a type I cryoglobulinemia with a cryoprecipitate composed of dual IgM (kappa and lambda). Further investigations on the cryoprecipitate revealed that the immunoglobulins were directed against SARS-CoV-2 antigens. In the meanwhile, our patient noticed improvement of his symptoms accompanied by resolution of laboratory abnormalities. Three months later, the cryoglobulin could no longer be detected.Type 1 cryoglobulinemia is usually associated with lymphoproliferative disorders and is characterized by various symptoms caused by cryoprecipitates occluding small blood vessels. This is, to our knowledge, the first case of type I cryoglobulinemia with proven precipitation of SARS-CoV-19 antibodies. COVID-19 induced cryoglobulinemia appears to have a mild disease course and to be self-limiting upon viral clearance.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: