Acute generalised exanthematous pustulosis and herpes simplex virus: a case of possible overlap.

Autor:	Zachian RL; Internal Medicine, Lankenau Medical Center, Wynnewood, Pennsylvania, USA rzachian@gmail.com.; Dermatology, University of Maryland, Baltimore, Maryland, USA., Sidhu BV; Internal Medicine, Lankenau Medical Center, Wynnewood, Pennsylvania, USA., Liu P; Internal Medicine, Lankenau Medical Center, Wynnewood, Pennsylvania, USA., Weimann R; Main Line Health System, King of Prussia, Pennsylvania, USA.; Schweiger Dermatology Group, King of Prussia, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2024 Aug 30; Vol. 17 (8). Date of Electronic Publication: 2024 Aug 30.
DOI:	10.1136/bcr-2024-260873
Abstrakt:	Acute generalised exanthematous pustulosis (AGEP) is a rare cutaneous disorder that presents with numerous non-follicular, pinpoint sterile pustules on a background of oedematous erythema that can coalesce, leading to desquamation. 90% of cases are triggered by medications, most often with antibiotics as the culprit. However, other triggers including viral infection have also been reported. Herpes simplex virus (HSV) as a viral trigger has not been previously explored. Here, we present a case of AGEP caused by bupropion, followed by a second presentation of assumed acute limited exanthematous pustulosis in the setting of disseminated HSV. This case may represent the first report of AGEP and HSV overlap. It also presents the interesting dilemma of differentiating AGEP and disseminated HSV (which can present similarly) as well as determining appropriate treatment and the utility versus risk of systemic steroid administration. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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