How the trabecular layer impacts on left ventricular function.

Autor: Visoiu IS; Department of Cardiology and Cardiovascular Surgery, SEARCH-VASC Center of Excellence, University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania., Jensen B; Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands. Electronic address: b.jensen@amsterdamumc.nl., Rimbas RC; Department of Cardiology and Cardiovascular Surgery, SEARCH-VASC Center of Excellence, University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania., Mihaila-Baldea S; Department of Cardiology and Cardiovascular Surgery, SEARCH-VASC Center of Excellence, University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania., Nicula AI; Department of Radiology, University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania., Vinereanu D; Department of Cardiology and Cardiovascular Surgery, SEARCH-VASC Center of Excellence, University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania.
Jazyk: angličtina
Zdroj: Journal of cardiology [J Cardiol] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1016/j.jjcc.2024.08.008
Abstrakt: The ventricular trabecular layer is crucial in embryonic life. In adults, the proportion of trabecular-to-compact myocardium varies substantially between individuals, within individuals over time, and yet exhibits almost no correlation to pump function since most individuals with excessive trabeculation are asymptomatic. The question of how functional is the myocardium of the trabecular layer, relative to the myocardium of the compact layer, has been difficult to answer but it is often assumed to be inferior. An answer is now emerging from recent advances and it can improve our understanding of how the trabecular layer impacts on pathogenicity. This narrative review concerns natural variation in trabeculation, tissue organization, transcriptomics, immunohistochemistry, vascularization, electrical propagation, diastolic function and compliance, systolic function, and ejection fraction. There are no overt transcriptional differences in the adult stage, and the myocardium is equally equipped with sarcomeric proteins, mitochondria, and vascular supply. The similar structural features are consistent with myocardium with a similar stroke work per gram tissue, along with a high ejection fraction of the trabecular layer. In conclusion, the myocardium of the trabecular and compact layers is highly similar and this offers a logical explanation for the reproducible observations that most individuals with excessive trabeculation are asymptomatic.
Competing Interests: Declaration of competing interest The authors declare that there is no competing interest.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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