Handheld Point-of-Care Devices for Snakebite Coagulopathy: A Scoping Review.

Autor:	Abouyannis M; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Marriott AE; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Stars E; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Kitchen DP; UK National External Quality Assessment Scheme for Blood Coagulation (UK NEQAS BC), Sheffield, United Kingdom., Kitchen S; UK National External Quality Assessment Scheme for Blood Coagulation (UK NEQAS BC), Sheffield, United Kingdom., Woods TAL; UK National External Quality Assessment Scheme for Blood Coagulation (UK NEQAS BC), Sheffield, United Kingdom., Kreuels B; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Amuasi JH; Department of Implementation Research, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Department of Global Health, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Monteiro WM; College of Health Sciences, University of the State of Amazonas, Manaus, Brazil.; Department of Teaching and Research, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Stienstra Y; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Department of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Senthilkumaran S; Department of Emergency and Critical Care, Manian Medical Centre, Erode, Tamil Nadu, India., Isbister GK; Clinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia., Lalloo DG; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Ainsworth S; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Casewell NR; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Jazyk:	angličtina
Zdroj:	Thrombosis and haemostasis [Thromb Haemost] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.
DOI:	10.1055/a-2407-1400
Abstrakt:	Venom-induced consumption coagulopathy (VICC) is a common complication of snakebite that is associated with hypofibrinogenemia, bleeding, disability, and death. In remote tropical settings, where most snakebites occur, the 20-minute whole blood clotting test is used to diagnose VICC. Point-of-care (POC) coagulation devices could provide an accessible means of detecting VICC that is better standardized, quantifiable, and more accurate. In this scoping review, the mechanistic reasons that previously studied POC devices have failed in VICC are considered, and evidence-based recommendations are made to prioritize certain devices for clinical validation studies. Four small studies have evaluated a POC international normalized ratio (INR) device in patients with Australian Elapid, Daboia russelii, and Echis carinatus envenoming. The devices assessed in these studies either relied on a thrombin substrate endpoint, which is known to underestimate INR in patients with hypofibrinogenemia, have been recalled due to poor accuracy, or have since been discontinued. Sixteen commercially available POC devices for measuring INR, activated clotting time, activated partial thromboplastin time, fibrinogen, D-dimer, and fibrin(ogen) degradation products have been reviewed. POC INR devices that detect fibrin clot formation, as well as a novel POC device that quantifies fibrinogen were identified, which show promise for use in patients with VICC. These devices could support more accurate allocation of antivenom, reduce the time to antivenom administration, and provide improved clinical trial outcome measurement instruments. There is an urgent need for these promising POC coagulation devices to be validated in prospective clinical snakebite studies. Competing Interests: None declared. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
Databáze:	MEDLINE
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