Prenatal detection of mild fetal ventriculomegaly - a systematic review of the modern literature.

Autor:	Sapantzoglou I; First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece., Asimakopoulos G; First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece., Fasoulakis Z; First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece., Tasias K; First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece., Daskalakis G; First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece., Antsaklis P; First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Ultraschall in der Medizin (Stuttgart, Germany : 1980) [Ultraschall Med] 2024 Aug 30. Date of Electronic Publication: 2024 Aug 30.
DOI:	10.1055/a-2375-0118
Abstrakt:	Introduction: While mild fetal ventriculomegaly is frequently observed as an incidental and benign finding, it is also known to be linked with structural, genetic, and neurodevelopmental abnormalities. The objective of this study was to conduct a systematic review of the existing literature in order to evaluate the association between apparently isolated fetal mild ventriculomegaly with the presence of additional structural defects detected by fetal brain MRI, chromosomal or other genetic anomalies, and neurodevelopmental delay. Methods: This systematic review was designed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Modern literature was searched from January 1, 2011, to July 31, 2023. Results: 23 studies were included, comprising a total of 2590 patients. Nine studies assessed the association between fetal mild ventriculomegaly and neurodevelopmental impairment, including 536 cases, with normal neurodevelopmental outcomes ranging from 64% to 96.5%. Ten studies evaluated the additive value of fetal MRI, including 1266 fetuses, with the detection rate of additional brain defects that eventually altered the clinical management ranging from 0% to 19.5%. Seven studies investigated the association of mild ventriculomegaly with the presence of underlying chromosomal or genetic conditions, including 747 cases, with the rate ranging from 1.1% to 15.4%. Conclusion: The prevalence of aneuploidy and genetic abnormalities in ventriculomegaly, especially in isolated cases, is reported to be quite low and the incidence of neurodevelopmental delay appears to be similar to that of the general population in cases that are apparently and truly isolated. Competing Interests: The authors declare that they have no conflict of interest. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
Databáze:	MEDLINE
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