Bacteroides ovatus alleviates dysbiotic microbiota-induced graft-versus-host disease.

Autor:	Hayase E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: ekhayase@gmail.com., Hayase T; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Mukherjee A; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Stinson SC; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jamal MA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Ortega MR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Sanchez CA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Ahmed SS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Karmouch JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Chang CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Flores II; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., McDaniel LK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Brown AN; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., El-Himri RK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Chapa VA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA., Tran BQ; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA., Xiao Y; Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Fan C; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Pham D; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Halsey TM; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Jin Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Tsai WB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Prasad R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Glover IK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Enkhbayar A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Mohammed A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Schmiester M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., King KY; Center for Cell and Gene Therapy and Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, USA., Britton RA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Reddy P; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Wong MC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Ajami NJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Shelburne S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Okhuysen PC; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Liu C; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA., Fowler SW; Department of Molecular Virology and Microbiology and Department of Education, Innovation, and Technology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Comparative Medicine and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Conner ME; Department of Molecular Virology and Microbiology and Department of Education, Innovation, and Technology, Baylor College of Medicine, Houston, TX 77030, USA., Katsamakis Z; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Smith N; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Burgos da Silva M; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ponce DM; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Peled JU; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10021, USA., van den Brink MRM; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10021, USA., Peterson CB; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rondon G; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Molldrem JJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Champlin RE; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lorenzi PL; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA., Mehta RS; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Martens EC; Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Alousi AM; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jenq RR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; CPRIT Scholar in Cancer Research, Houston, TX, USA. Electronic address: rjenq@coh.org.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2024 Sep 11; Vol. 32 (9), pp. 1621-1636.e6. Date of Electronic Publication: 2024 Aug 29.
DOI:	10.1016/j.chom.2024.08.004
Abstrakt:	Acute lower gastrointestinal GVHD (aLGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation. Although the intestinal microbiota is associated with the incidence of aLGI-GVHD, how the intestinal microbiota impacts treatment responses in aLGI-GVHD has not been thoroughly studied. In a cohort of patients with aLGI-GVHD (n = 37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and a disrupted fecal microbiome characterized by reduced abundances of Bacteroides ovatus. In a murine GVHD model aggravated by carbapenem antibiotics, introducing B. ovatus reduced GVHD severity and improved survival. These beneficial effects of Bacteroides ovatus were linked to its ability to metabolize dietary polysaccharides into monosaccharides, which suppressed the mucus-degrading capabilities of colonic mucus degraders such as Bacteroides thetaiotaomicron and Akkermansia muciniphila, thus reducing GVHD-related mortality. Collectively, these findings reveal the importance of microbiota in aLGI-GVHD and therapeutic potential of B. ovatus. Competing Interests: Declaration of interests R.R.J. has served as a consultant or advisory board member for Postbiotics Plus, Merck, Microbiome DX, Karius, MaaT Pharma, LISCure, Seres, Kaleido, and Prolacta and has received patent license fee or stock options from Seres, Kaleido, and Postbiotics Plus. E.J.S. has served as a consultant or advisory board member for Adaptimmune, Axio, Navan, Fibroblasts, and FibroBiologics, NY Blood Center, and Celaid Therapeutics and has received patent license fee from Takeda and Affimed. J.U.P. reports research funding, intellectual property fees, and travel reimbursement from Seres Therapeutics, and consulting fees from DaVolterra, CSL Behring, Crestone Inc, and from MaaT Pharma. J.U.P. serves on an advisory board of and holds equity in Postbiotics Plus Research. J.U.P. has filed intellectual property applications related to the microbiome (reference numbers #62/843,849, #62/977,908, and #15/756,845). Memorial Sloan Kettering Cancer Center (MSK) has financial interests relative to Seres Therapeutics. E.H., M.A.J., J.L.K., and R.R.J. are inventors on a patent application by The University of Texas MD Anderson Cancer Center supported by results of the current study entitled, “Methods and Compositions for Treating Cancer therapy-induced Neutropenic Fever and/or GVHD.” (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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