Case-control study of IL23R rs76418789 polymorphism, smoking, and ulcerative colitis in Japan.

Autor: Miyake Y; Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan. Electronic address: miyake.yoshihiro.ls@ehime-u.ac.jp., Tanaka K; Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime, Japan., Nagata C; Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan., Furukawa S; Health Services Center, Ehime University, Ehime, Japan., Andoh A; Department of Medicine, Shiga University of Medical Science, Shiga, Japan., Yokoyama T; Department of Health Promotion, National Institute of Public Health, Saitama, Japan., Yoshimura N; Ohori IBD Clinic, Tokyo, Japan., Mori K; Gastroenterology Center, Ehime Prefectural Central Hospital, Ehime, Japan., Ninomiya T; Gastroenterology Center, Ehime Prefectural Central Hospital, Ehime, Japan., Yamamoto Y; Endoscopy Center, Ehime University Hospital, Ehime, Japan., Takeshita E; Center for Inflammatory Bowel Diseases, Ehime University Hospital, Ehime, Japan., Ikeda Y; Endoscopy Center, Ehime University Hospital, Ehime, Japan., Saito M; Department of Gastroenterology, Tokuyama Central Hospital, Yamaguchi, Japan., Ohashi K; Ohashi Clinic Participate in Gastro-Enterology and Ano-Proctology, Ehime, Japan., Imaeda H; Department of Medicine, Shiga University of Medical Science, Shiga, Japan., Kakimoto K; Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan., Higuchi K; Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan., Nunoi H; Kato Internal Medicine, Ehime, Japan., Mizukami Y; Department of Gastroenterology, Matsuyama Shimin Hospital, Ehime, Japan., Suzuki S; Sumitomo Besshi Hospital, Ehime, Japan., Hiraoka S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Okada H; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Kawasaki K; Department of Internal Medicine and Gastroenterology, Saiseikai Imabari Hospital, Ehime, Japan., Higashiyama M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan., Hokari R; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan., Miura H; Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan., Miyake T; Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan., Kumagi T; Postgraduate Clinical Training Center, Ehime University Hospital, Ehime, Japan., Kato H; Kato Dental Clinic, Ehime, Japan., Hato N; Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Ehime, Japan., Sayama K; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan., Hiasa Y; Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2024 Nov; Vol. 183, pp. 156743. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.cyto.2024.156743
Abstrakt: Background: Interleukin (IL)-23 is involved in the pathogenesis of ulcerative colitis (UC). A genome-wide significant association between IL23R p.G149R (rs76418789) and UC was previously identified in Japan and Korea. This case-control study aims to examine this association within the Japanese population.
Methods: The study included 384 cases diagnosed with UC within the past 4 years and 661 control subjects. Adjustment was made for sex, age, and smoking.
Results: The frequency of the AA genotype of rs76418789 was 0.0 % in cases and 0.5 % in control subjects. In comparison to study subjects with the GG genotype of rs76418789, those with the GA or AA genotype had a significantly reduced risk of UC, with an adjusted odds ratio of 0.67 (95 % confidence interval: 0.44-0.999). A significant multiplicative interaction was observed between rs76418789 and having ever smoked influencing UC (p for interaction = 0.03). A significant positive association was found between having ever smoked and UC in individuals with at least one A allele, while no such positive relationship was observed in those with the GG genotype.
Conclusion: IL23R SNP rs76418789 showed a significant association with UC. This study provides new evidence regarding the interaction between rs76418789 and smoking in relation to UC.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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