Nitrite reductase-mimicking catalysis temporally regulating nitric oxide concentration gradient adaptive for antibacterial therapy.

Autor:	Feng Y; Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China., Yu Y; Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China., Shi H; Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China., Bai J; Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China., Wang L; Department of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China., Yang T; Department of Ophthalmology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China., Liu L; Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2024 Aug 30; Vol. 10 (35), pp. eadp5935. Date of Electronic Publication: 2024 Aug 30.
DOI:	10.1126/sciadv.adp5935
Abstrakt:	The unique bacterial infection microenvironment (IME) usually requires complicated design of nanomaterials to adapt to IME for enhancing antibacterial therapy. Here, an alternative IME adaptative nitrite reductase-mimicking nanozyme is constructed by in situ growth of ultrasmall copper sulfide clusters on the surface of a nanofibrillar lysozyme assembly (NFLA/CuS NHs), which can temporally regulate nitric oxide (NO) gradient concentration to kill bacteria initially and promote tissue regeneration subsequently. Benefiting from a copper nitrite reductase (CuNIR)-inspired structure with CuS cluster as active center and NFLA as skeleton, NFLA/CuS NHs efficiently boost the catalytic reduction of nitrite to NO. The inherent supramolecular fibrillar networks displays excellent bacterial capture capability, facilitating initial high-concentration NO attacks on the bacteria. The subsequent catalytic release of low-concentration NO by NFLA/CuS NHs-mediated nitrite reduction remarkably promotes cell migration and angiogenesis. This work paves the way for dynamically eliminating MDR bacterial infection and promoting tissue regeneration in a simple and smart way through CuNIR-mimicking catalysis.
Databáze:	MEDLINE
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