PAX6 protein in neuromasts of the lateral line system of salamanders (Eurycea).

Autor: Dobbins BA; Department of Biology, Texas State University, San Marcos, TX, United States of America., Tovar RU; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, United States of America., Oddo BJ; Department of Biology, Texas State University, San Marcos, TX, United States of America., Teague CG; Department of Biology, Texas State University, San Marcos, TX, United States of America., Sindhi NA; Department of Biology, Texas State University, San Marcos, TX, United States of America., Devitt TJ; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, United States of America., Hillis DM; Department of Integrative Biology, The University of Texas at Austin, Austin, TX, United States of America., García DM; Department of Biology, Texas State University, San Marcos, TX, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Aug 30; Vol. 19 (8), pp. e0293163. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0293163
Abstrakt: PAX6 is well known as a transcription factor that drives eye development in animals as widely divergent as flies and mammals. In addition to its localization in eyes, PAX6 expression has been reported in the central nervous system, the pancreas, testes, Merkel cells, nasal epithelium, developing cells of the inner ear, and embryonic submandibular salivary gland. Here we show that PAX6 also appears to be present in the mechanosensory neuromasts of the lateral line system in paedomorphic salamanders of the genus Eurycea. Using immunohistochemistry and confocal microscopy to examine a limited number of larvae of two species, listed by the United States of America's federal government as threatened (E. nana) or endangered (E. rathbuni), we found that anti-PAX6 antibody labeled structures that were extranuclear, and labeling was most intense in the apical appendages of the hair cells of the neuromast. This extranuclear localization raises the possibility of an as yet undescribed function for PAX6 as a cytoskeleton-associated protein.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Dobbins et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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