Rh(III)-Catalyzed Sequential ortho-C-H Bond Annulation and Desulfonylation of 3-Aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides: Access to 1-Aminoisoquinolines.
| Autor: | Ajay C; Fluoro &Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Balasubramanian S; Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India., Subba Reddy BV; Fluoro &Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry, an Asian journal [Chem Asian J] 2024 Aug 30, pp. e202400723. Date of Electronic Publication: 2024 Aug 30. |
| DOI: | 10.1002/asia.202400723 |
| Abstrakt: | An efficient Rh(III)-catalyzed C-H functionalization of 3-aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides with diaryl and dialkyl alkynes has been developed for the first time to the synthesis of 1-aminoisoquinoline derivatives in a single step. This method involves through the formation of one C-C bond and one C-N bond followed by desulfonylation to generate a novel series of isoquinolines in good to excellent yields. This is a direct method to produce pharmaceutically more relevant scaffolds with a high functional diversity. (© 2024 Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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