Suppression of NLRP3 inflammasome orchestrates the protective efficacy of tiron against isoprenaline-induced myocardial injury.

Autor:	Abdelrahaman D; Department of Internal Medicine, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Habotta OA; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt., Taher ES; Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan., El-Ashry ES; Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt., Ibrahim I; Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt., Abdeen A; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt., Ibrahim AM; Department of Administration and Nursing Education, College of Nursing, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.; Department of Family and Community Health Nursing, Faculty of Nursing, Port-Said University, Port Said, Egypt., Ibrahim RM; Department of Physiology, Faculty of Medicine, Benha University, Benha, Egypt., Anwer H; Department of Physiology, Faculty of Medicine, Benha University, Benha, Egypt., Mihaela O; Department of Biology, Faculty of Agriculture, University of Life Sciences'King Michael I' from Timisoara, Timisoara, Romania., Olga R; Department of Biology, Faculty of Agriculture, University of Life Sciences'King Michael I' from Timisoara, Timisoara, Romania., Alwutayed KM; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Al-Serwi RH; Department of Basic Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., El-Sherbiny M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia., Sorour SM; Department of Pharmacology, Faculty of Medicine, Benha University, Benha, Egypt., El-Kashef DH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Aug 15; Vol. 15, pp. 1379908. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1379908
Abstrakt:	The major contribution of myocardial damage to global mortalities raises debate regarding the exploration of new therapeutic strategies for its treatment. Therefore, our study investigated the counteracting effect of tiron against isoprenaline (ISO)-mediated cardiac infarction in mice. Tiron was administered to mice for 7 days prior to two consecutive injections of ISO on days 8 and 9 of the treatment protocol. Tiron significantly reduced the levels of CK-MB, LDH, and AST in serum samples of ISO-challenged mice. A considerable increase in the cardiac antioxidant response was observed in tiron-treated mice, as indicated by depletion of MDA and enhancement of antioxidant activities. Furthermore, tiron induced a marked decrease in NLRP3, ASC, and caspase-1 levels accompanied by weak immune reactions of IL-1β, NF-κB, TLR4, and iNOS in the infarct cardiac tissues. Histopathological screening validated these variations observed in the cardiac specimens. Thus, tiron clearly mitigated the oxidative and inflammatory stress by repressing the NLRP3 inflammasome and the TLR4/NF-κB/iNOS signaling cascade. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Abdelrahaman, Habotta, Taher, El-Ashry, Ibrahim, Abdeen, Ibrahim, Ibrahim, Anwer, Mihaela, Olga, Alwutayed, Al-Serwi, El-Sherbiny, Sorour and El-Kashef.)
Databáze:	MEDLINE
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