Chronic Obstructive Pulmonary Disease and the Omicron Variant of COVID-19 Prognosis: A Retrospective Cohort Study.

Autor:	Leung CCD; Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, HKG., Yu ELM; Clinical Research Centre, Kowloon West Cluster, Hong Kong, HKG., Chan YH; Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, HKG., Ho MY; Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, HKG., Kwok CT; Respiratory Medicine, Kowloon Hospital, Hong Kong, HKG., Chan HCC; Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, HKG., Yeung YC; Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, HKG.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 29; Vol. 16 (7), pp. e65713. Date of Electronic Publication: 2024 Jul 29 (Print Publication: 2024).
DOI:	10.7759/cureus.65713
Abstrakt:	Background and Aim: This retrospective cohort study aimed to investigate the association between chronic obstructive pulmonary disease (COPD) and the prognosis of COVID-19 patients infected with the Omicron variant. The primary objective was to determine if COVID-19 patients with COPD had higher mortality rates compared to those without COPD. Secondary objectives included assessing the risk of respiratory failure, hospital stay length, intensive care unit (ICU) admission, and oxygen requirements in COPD patients with COVID-19. Materials and Methods: The study included 2761 COVID-19 patients admitted to the Princess Margaret Hospital, Hong Kong, between January 1 and June 30, 2022. Among them, 7.4% (n = 205) had COPD. Demographic and clinical data, including vaccination status and comorbidities, were collected. The primary outcome was 30-day mortality, and secondary outcomes included respiratory support requirement, hospital stay length, and ICU admission. Logistic regression analyses were conducted, adjusting for potential confounders. Results: COPD did not independently increase the risk of COVID-19 mortality after adjusting for confounders. Instead, older age, male sex, incomplete vaccination, long-term oxygen therapy use, and specific comorbidities were identified as significant predictors of 30-day mortality. COPD patients were more likely to require oxygen and noninvasive ventilation, but there were no significant differences in other secondary outcomes compared to non-COPD patients. Conclusion: COPD itself was not an independent risk factor for COVID-19 mortality. Age, sex, vaccination status, comorbidities, and long-term oxygen therapy use were important predictors of mortality. These findings underscore the importance of considering multiple factors when assessing the impact of COPD on COVID-19 prognosis, particularly with the Omicron variant. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Research Ethics Committee of the Kowloon West Cluster of the Hong Kong Hospital Authority issued approval KW/EX-23-018(181-08). This is a retrospective analysis of existing data, which involves no additional interventions for subjects. This study was carried out in accordance with the Declaration of Helsinki, and there was no major ethical issue. It was approved by the Research Ethics Committee of the Kowloon West Cluster of the Hong Kong Hospital Authority (Reference No. KW/EX-23-018(181-08)). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Leung et al.)
Databáze:	MEDLINE
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