Analysis of Depression and Anxiety Scores Following Initiation of Elexacaftor/Tezacaftor/Ivacaftor in Adults With Cystic Fibrosis.

Autor: Pudukodu H; Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA., Powell MZ; Department of Psychology and Neuroscience, Baylor University, Waco, Texas, USA., Ceppe A; Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Donaldson SH; Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Goralski JL; Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Sowa NA; Department of Psychiatry, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Jazyk: angličtina
Zdroj: The clinical respiratory journal [Clin Respir J] 2024 Sep; Vol. 18 (9), pp. e70007.
DOI: 10.1111/crj.70007
Abstrakt: Objective: Elexacaftor/tezacaftor/ivacaftor (E/T/I) has provided life-changing pharmacotherapy for many people with cystic fibrosis (CF), but conflicting literature exists regarding the effect on mental health. While some reports suggest E/T/I may induce adverse psychiatric symptoms, others report improvements in mental health symptoms. To add to this growing body of knowledge, we retrospectively analyzed depression and anxiety symptoms before and after E/T/I initiation in adults with CF at a single large US CF center.
Method: Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scores recorded in a database were studied. Patients with scores collected before and after E/T/I initiation were included. Regression analyses described associations between score changes and age, race, ethnicity, sex, CFTR variant, and prior depression and/or anxiety diagnoses. Secondary analyses examined possible confounding effects of the COVID-19 pandemic.
Results: There was no change in mean GAD-7 (0.5 ± 5.3, p = 0.41) or PHQ-9 (-0.02 ± 6.0, p = 0.97) scores following initiation of E/T/I (N = 86). A trend between a prior diagnosis of depression and worsening in PHQ-9 post-E/T/I was observed (OR 3.58; p = 0.054).
Conclusions: Treatment with E/T/I does not lead to changes in depression or anxiety symptoms at the population level in this single center cohort study. A prior diagnosis of depression trended towards an increased odds of worsening PHQ-9 scores after E/T/I initiation.
(© 2024 The Author(s). The Clinical Respiratory Journal published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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