| Autor: |
J N; Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai - 602105, India., Anandhi B; The Erode College of Pharmacy, Erode, India., Patnaik SS; Guru Nanak Institutions Technical Campus, India., Shirole RL; Department of Pharmacology, DCS's A.R.A. College of Pharmacy, Nagaon, Dhule (MS) India., Mourya ND; School of Pharmacy, Rai University, Gujarat, India., Siddiqui N; CMR College of Pharmacy, Kandlakoya, Hyderabad, Telangana, India., Mathew J; Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Deralakatte, Paneer, Mangalore, Karnataka, India., Ravikkumar VR; Dept. of Pharmacognosy, The Erode College of Pharmacy , Tamil Nadu Dr MGR Medical University Chennai, Perundurai Main Road, Veppampalayam, Erode-638112, Tamil Nadu, India., Karthikeyan E; Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, Tamilnadu, India. |
| Abstrakt: |
The main issue with Hypertension therapy is quick commencement of effect. The creation of suitable dose forms may help address the issue of medications having a delayed beginning of effect. Oral Antihypertensive medication treatment is best suited for and has seen a rise in popularity with fast-disintegrating tablets. In terms of patient compliance, quick start of action, precise dosage, strong chemical stability, ease of self-administration, and compactness, they are superior to other traditional methods. As a popular hypertension medication, Propranolol HCl is a strong candidate for development into Fast Dissolving Tablets (FDTs). Because to first pass metabolism, it has a limited bioavailability. Therefore, the primary goal of the research was to create Propranolol HCl fast-dissolving tablets in order to increase the drug's bioavailability and dissolution rate. Microcrystalline cellulose used to make fast-dissolving Propranolol HCl tablets, together with varying concentrations of super disintegrates such as Chia Seed mucilage and sodium starch glycolate. Each batch was made by compressing it directly. Three formulation variables were combined, and the combined impact was examined using a 23 Full Factorial design. Here, the disintegration time is examined as a dependent parameter and the concentrations of chia seed mucilage, Sodium Starch Glycolate, and Microcrystalline Cellulose were considered as independent variables, X1, X2, and X3, respectively. The program Design Expert is used to depict the data. |
