In-Clinic and Natural Gait Observations master protocol (I-CAN-GO) to validate gait using a lumbar accelerometer.

Autor: Welbourn M; Pfizer, Inc, Cambridge, MA, USA., Sheriff P; Pfizer, Inc, Cambridge, MA, USA., Tuttle PG; Pfizer, Inc, Cambridge, MA, USA., Adamowicz L; Pfizer, Inc, Cambridge, MA, USA., Psaltos D; Pfizer, Inc, Cambridge, MA, USA., Kelekar A; Pfizer, Inc, Cambridge, MA, USA., Selig J; Pfizer, Inc, Cambridge, MA, USA., Messere A; Pfizer, Inc, Cambridge, MA, USA., Mei W; Pfizer, Inc, Cambridge, MA, USA., Caouette D; Pfizer, Inc, Cambridge, MA, USA., Ghafoor S; Pfizer, Inc, Cambridge, MA, USA., Santamaria M; Pfizer, Inc, Cambridge, MA, USA., Zhang H; Pfizer, Inc, Cambridge, MA, USA., Demanuele C; Pfizer, Inc, Cambridge, MA, USA., Karahanoglu FI; Pfizer, Inc, Cambridge, MA, USA., Cai X; Pfizer, Inc, Cambridge, MA, USA. xuemei.cai@pfizer.com.; Tufts Medical Center, Boston, MA, USA. xuemei.cai@pfizer.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 29; Vol. 14 (1), pp. 20128. Date of Electronic Publication: 2024 Aug 29.
DOI: 10.1038/s41598-024-67675-6
Abstrakt: Traditional measurements of gait are typically performed in clinical or laboratory settings where functional assessments are used to collect episodic data, which may not reflect naturalistic gait and activity patterns. The emergence of digital health technologies has enabled reliable and continuous representation of gait and activity in free-living environments. To provide further evidence for naturalistic gait characterization, we designed a master protocol to validate and evaluate the performance of a method for measuring gait derived from a single lumbar-worn accelerometer with respect to reference methods. This evaluation included distinguishing between participants' self-perceived different gait speed levels, and effects of different floor surfaces such as carpet and tile on walking performance, and performance under different bouts, speed, and duration of walking during a wide range of simulated daily activities. Using data from 20 healthy adult participants, we found different self-paced walking speeds and floor surface effects can be accurately characterized. Furthermore, we showed accurate representation of gait and activity during simulated daily living activities and longer bouts of outside walking. Participants in general found that the devices were comfortable. These results extend our previous validation of the method to more naturalistic setting and increases confidence of implementation at-home.
(© 2024. The Author(s).)
Databáze: MEDLINE
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