Oral manifestations of peripheral T cell lymphoma, not otherwise specified: case series and review of the current literature.

Autor: de Oliveira EM; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., de Cáceres CVBL; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Fernandes-Rodrigues CI; Oral Pathology Unit, Department of Clinic and Preventive Dentistry, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Penafort PVM; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Legarrea JMA; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gomes NR; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Pontes HAR; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Vargas PA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Júnior JNRA; Santa Casa Hospital, Santos, Brazil., Soares CD; Getúlio Sales Diagnósticos Laboratory, Natal, Brazil., Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: felipepfonseca@hotmail.com.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2024 Aug 17. Date of Electronic Publication: 2024 Aug 17.
DOI: 10.1016/j.oooo.2024.08.011
Abstrakt: Objective: The objective of this study was to describe a series of peripheral T-cell lymphoma, not otherwise specified (PTCL NOS) affecting the oral cavity and to review the available literature.
Study Design: Cases diagnosed as PTCL-NOS affecting the oral cavity were retrospectively retrieved from pathology files. Original hematoxylin and eosin-stained slides and immunohistochemical reactions were reviewed for microscopic confirmation. The presence of Epstein-Barr virus (EBV) was investigated by in situ hybridization. Clinical and follow-up data were retrieved from patients' pathology and medical files.
Results: A total of 5 cases were obtained with a mean age of 51.8 years old, 3 male patients and 2 female patients. Three cases affected the palate and 2 cases affected the gingiva, whereas 1 case affected the maxillary bone. Tumors presented as destructive, infiltrative, and painful lesions causing swelling, ulceration, and tissue necrosis. All cases exhibited CD3 expression. GATA3 was expressed in 3 cases. Four patients were deceased of the disease during follow-up.
Conclusions: PTCL NOS affecting the oral cavity is rare and usually present as a very aggressive disease, associated with a poor prognosis and dismal outcome. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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