Cardiovascular disease risk in people of African ancestry with HIV in the United Kingdom.

Autor: Ko S; King's College Hospital NHS Foundation Trust, London, UK., Dominguez-Dominguez L; King's College Hospital NHS Foundation Trust, London, UK.; Berkshire Healthcare NHS Foundation Trust, Slough, UK., Ottaway Z; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK., Campbell L; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK., Fox J; King's College London, London, UK.; Guys and St Thomas's NHS Foundation Trust, London, UK., Burns F; Royal Free London NHS Foundation Trust, London, UK.; Institute for Global Health, University College London, London, UK., Hamzah L; St Georges University Hospital NHS Foundation Trust, London, UK., Ustianowski A; Manchester University NHS Foundation Trust, Manchester, UK., Clarke A; University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Kegg S; Lewisham and Greenwich NHS Trust, London, UK., Schoeman S; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Jones R; Chelsea and Westminster NHS Foundation Trust, London, UK., Pett SL; Institute for Global Health, University College London, London, UK.; Central and North West London NHS Foundation Trust, London, UK., Hudson J; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK., Post FA; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK.
Jazyk: angličtina
Zdroj: HIV medicine [HIV Med] 2024 Dec; Vol. 25 (12), pp. 1289-1297. Date of Electronic Publication: 2024 Aug 29.
DOI: 10.1111/hiv.13706
Abstrakt: Objectives: Our objective was to describe the prevalence of cardiovascular disease (CVD) risk factors in people of African ancestry with HIV in the UK.
Methods: We conducted a cross-sectional analysis of CVD risk factors in Black people with HIV aged ≥40 years and estimated the 10-year CVD risk using QRISK®3-2018. Correlations between body mass index (BMI) and CVD risk factors were described using Pearson correlation coefficients, and factors associated with 10-year CVD risk ≥5% were described using logistic regression.
Results: We included 833 Black people with HIV and a median age of 54 years; 54% were female, 50% were living with obesity (BMI ≥30 kg/m 2 ), 61% had hypertension, and 19% had diabetes mellitus. CVD risk >5% ranged from 2% in female participants aged 40-49 years to 99% in men aged ≥60 years, and use of statins ranged from 7% in those with CVD risk <2.5% to 64% in those with CVD risk ≥20%. BMI was correlated (R 2 0.1-0.2) with triglycerides and diastolic blood pressure in women and with glycated haemoglobin, systolic and diastolic blood pressure, and total:high-density lipoprotein (HDL) cholesterol ratio in men. In both female and male participants, older age, blood pressure, diabetes mellitus, and kidney disease were strongly associated with CVD risk ≥5%, whereas obesity, total:HDL cholesterol, triglycerides, and smoking status were variably associated with CVD risk ≥5%.
Conclusions: We report a high burden of CVD risk factors, including obesity, hypertension, and diabetes mellitus, in people of African ancestry with HIV in the UK. BMI-focused interventions in these populations may improve CVD risk while also addressing other important health issues.
(© 2024 The Author(s). HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.)
Databáze: MEDLINE
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