Association between changes in glycosylated hemoglobin during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy.

Autor: Hu M; Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Obstetrical Department, Shaoxing Keqiao Women & Children's Hospital, Shaoxing, Zhejiang, China., Liang S; Obstetrical Department, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China., Wu Q; Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Shin Lee C; Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Lu J; Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Bao S; Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Wu C; Obstetrical Department, Shaoxing Keqiao Women & Children's Hospital, Shaoxing, Zhejiang, China. Electronic address: wucy96@hotmail.com., Liang Z; Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States. Electronic address: xiaozaizai@zju.edu.cn.
Jazyk: angličtina
Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2024 Oct; Vol. 216, pp. 111841. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1016/j.diabres.2024.111841
Abstrakt: Objective: To explore the relationship between changes in glycated hemoglobin (HbA1c) during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy (HIP).
Research Design and Methods: A total of 1,057 pregnant women who underwent serum HbA1c and delivered at Women's Hospital, Zhejiang University School of Medicine from May 2022 to March 2023, were included in this study. They were divided into four groups. Associations were evaluated using multivariate logistic regression analysis.
Results: In our study, an upward trend in HbA1c levels in the second trimester (HbA1c_S) and third trimester (HbA1c_T) among women without HIP was demonstrated. Multivariate logistics regression analysis showed significant associations: Pregnant women with HbA1c_S<5.5 %, HbA1c_T≥6.1 %, or with HbA1c_S≥5.5 %, HbA1c_T<6.1 % had a significant correlation with hypertensive disorders of pregnancy (HDP) (aOR:2.72, 95 %CI=1.24-5.97；aOR:2.59, 95 %CI=1.15-5.84). Furthermore, for each 1 % increase in the difference value of HbA1c between the second and third trimesters, the risk of HDP increased about 1.96 times, and the risk of delivering a large-for-gestational-age baby increased about 1.30 times.
Conclusion: Among pregnant women without HIP, elevated HbA1c levels in the second or third trimester are associated with increased risks of adverse pregnancy outcomes.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Zhaoxia Liang reports financial support was provided by Medical and Health Technology Program of Zhejiang Province. Zhaoxia Liang reports financial support was provided by Key R&D Program of Zhejiang. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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