Intra-uterine injection of amnion-derived acellular bioscaffold product in mares, a description of systemic and intra-uterine effects over 21 days.
Autor: | Kelley D; Oklahoma State University, College of Veterinary Medicine, Stillwater, OK, United States. Electronic address: dale.kelley@okstate.edu., Walbornn S; Rood & Riddle Equine Hospital, Lexington, KY, United States., Bartley C; Rood & Riddle Equine Hospital, Lexington, KY, United States., Kaczor J; Rood & Riddle Equine Hospital, Lexington, KY, United States., Premanandan C; The Ohio State University, College of Veterinary Medicine, Columbus, OH United States., Newton N; Rood & Riddle Equine Hospital, Lexington, KY, United States., Holland R; Holland Management Services Inc., Lexington, KY, United States., Schnobrich M; Rood & Riddle Equine Hospital, Lexington, KY, United States. |
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Jazyk: | angličtina |
Zdroj: | Journal of equine veterinary science [J Equine Vet Sci] 2024 Nov; Vol. 142, pp. 105180. Date of Electronic Publication: 2024 Aug 30. |
DOI: | 10.1016/j.jevs.2024.105180 |
Abstrakt: | Amnion-derived acellular bioscaffold (ADABP) products demonstrate interesting anti-inflammatory and healing properties which could be beneficial for intrauterine use. The objective of this study was to evaluate the safety of intrauterine injection of ADABP on systemic and uterine health. The study design randomly assigned subjects to one of two groups, control mares (n = 3) which received 3 mL injection of sterile saline in the base of each uterine horn, and treatment mares (n = 9) which received 3 mL of ADABP in the base of one uterine horn and 3 mL injection of sterile saline in the base of the other uterine horn. The leukogram had no significant effect of group and no group by day interaction. The serum biochemistry panel had no effect of group on any of the parameters examined. There were no significant differences in uterine culture or uterine biopsy results. The data suggests intrauterine injection of ADABP has no negative systemic or uterine effects. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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