Multifunctional targeting of docetaxel plus bakuchiol micelles in the treatment of invasion and metastasis of ovarian cancer.

Autor: Li QY; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China., Zhu RR; Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong 250011, People's Republic of China., Yu HY; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China., Liu CL; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China., Diao FY; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China., Jiang YQ; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China., Lin YQ; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China., Li XT; Liaoning University of Traditional Chinese Medicine, School of Pharmacy, Dalian 116600, People's Republic of China., Wang WJ; Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China.
Jazyk: angličtina
Zdroj: Biomedical materials (Bristol, England) [Biomed Mater] 2024 Sep 05; Vol. 19 (6). Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1088/1748-605X/ad7556
Abstrakt: The invasion and metastasis of tumors pose significant challenges in the treatment of ovarian cancer (OC), making it difficult to cure. One potential treatment approach that has gained attention is the use of matrix metalloproteinase reactive controlled release micelle preparations. In this study, we developed a novel PEG 5000 -PVGLIG-hyaluronic acid docetaxel/bakuchiol (PP-HA-DTX/BAK) micelles formulation with desirable characteristics such as particle size, narrow polydispersity index, and a ZETA potential of approximately -5 mV. The surface modification with HA facilitates tumor penetration into the tumor interior, while the incorporation of DSPE-PEG 2000 -PVGLIG-PEG 5000 helps conceal DSPE-PEG 2000 -HA, reducing off-target effects and prolonging drug circulation time in vivo . Both in vitro and in vivo experiments demonstrated that these micelles effectively inhibit proliferation, invasion, and metastasis of OC cells while promoting apoptosis. Therefore, our findings suggest that PP-HA-DTX/BAK micelles represent a safe and effective therapeutic strategy for treating OC.
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Databáze: MEDLINE
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