Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition.

Autor: Mlakar V; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: vid.2.mlakar@kcl.ac.uk., Akkouh I; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo, Norway., Halff EF; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Srivastava DP; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK., Birkenæs V; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo, Norway., Ueland T; Section for Clinical Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Norway; Department of Psychology, University of Oslo, Oslo, Norway., Quintana DS; Department of Psychology, University of Oslo, Oslo, Norway; NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway., Ormerod MBEG; Section for Clinical Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Norway., Steen NE; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo, Norway; Section for Clinical Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Norway; Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway., Andreassen OA; Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo, Norway., Aas M; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, England, UK.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 Oct; Vol. 272, pp. 89-95. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1016/j.schres.2024.08.011
Abstrakt: Objective: Contemporary research suggests reduced telomere length in schizophrenia spectrum disorders (SZ) compared to age-adjusted non-affected individuals. However, the role of telomere maintenance and telomere repair in SZ is poorly understood as well as the involvement of telomere biology in cognitive abnormalities in SZ.
Methods: The study consisted of 758 participants (SZ [n = 357] and healthy controls, HC [n = 401]) collected as part of the Norwegian TOP study. Participants were assessed with standardized neuropsychological tests measuring five cognitive domains. Leucocyte telomere length (TL) was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio), used to estimate the mean telomere length. Telomerase activity was assessed by the expression levels of the Telomerase Reverse Transcriptase (TERT) and Telomerase RNA Component (TERC) genes. To assess telomere maintenance and telomere repair we calculated the telomerase expression to TL ratio (TERT/TL and TERC/TL respectively).
Results: Patients had reduced TERT (F = 5.03, p = 0.03), but not TERC expression (F = 1.04, p = 0.31), and higher TERT/TL (F = 6.68, p = 0.01) and TERC/TL (F = 6.71, p = 0.01), adjusted for age, sex, and ethnicity. No statistically significant association was observed between any of the telomere biology markers and the cognitive domains (p > 0.05).
Conclusion: Our study shows changes in TERT expression and telomere maintenance and telomere repair in SZ compared HC. However, the role of telomere biology in the mechanism underlying cognitive impairment in psychosis seems limited.
Competing Interests: Declaration of competing interest Authors declare no conflict of interests.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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