Research progress of the Otubains subfamily in hepatocellular carcinoma.

Autor: Wu Y; Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas, Penang 13200, Malaysia. Electronic address: wuyanming@student.usm.my., Mohd Sani SB; Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas, Penang 13200, Malaysia. Electronic address: saudahbadriah@student.usm.my., Peng K; Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, China. Electronic address: pengke202403@163.com., Lin T; Department of General Surgery, Anyang People's Hospital, Anyang, Henan 450000, China. Electronic address: linhaitingsha@163.com., Tan C; Department of Social Science, Universiti Sain Malaysia, Gelugor, Penang 11700, Malaysia. Electronic address: chenghao2238@student.usm.my., Huang X; University of Debrecen, Debrecen 4032, Hungary. Electronic address: huangxufeng@mailbox.unideb.hu., Li Z; Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China. Electronic address: lzr_0108@sjtu.edu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Oct; Vol. 179, pp. 117348. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1016/j.biopha.2024.117348
Abstrakt: In cancer research, oncogenesis can be affected by modulating the deubiquitination pathway. Ubiquitination regulates proteins post-translationally in variety of physiological processes. The Otubain Subfamily includes OTUB1 (ovarian tumor-associated proteinase B1) and OTUB2(ovarian tumor-associated proteinase B2). They are deubiquitinating enzymes, which are research hotspots in tumor immunotherapy, with their implications extending across the spectrum of tumor development. Understanding their important role in tumorigenesis, includ-ing hepatocellular carcinoma (HCC) is crucial. HCC has alarming global incidence rates and mortality statistics, ranking among the top five prevalent cancers in Malaysia 1 . Numerous studies have consistently indicated significant expression of OTUB1 and OTUB2 in HCC cells. In addition, OTUB1 has important biological functions in cancer, suggesting its important role in tumorigenesis. However, the mechanism underlying the action of OTUB1 and OTUB2 in liver cancer remains inadequately explored. Therefore, Otubain Subfamily, as potential molecular target, holds promise for advancing HCC treatments. However, further clinical studies are required to verify its efficacy and application prospects.
Competing Interests: Declaration of Competing Interest The authors declare that Copilot and QuillBot tools were used for translation and language polishing in the writing of this manuscript. This tool was used only to improve the linguistic quality of the articles and was used under the supervision of a human author. The authors take full responsibility for the accuracy and completeness of the content of the article and confirm that the tool was not used for any activity that might give rise to a conflict of interest other than the use described above. The views expressed in this article are solely those of the authors and have not been influenced by any funding agency or commercial entity.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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