Differential tissue distribution of pharmaceuticals in a wild subtropical marine fish.

Autor: Castillo NA; Earth and Environment Department, Florida International University, Miami, FL, USA. Electronic address: ncast169@fiu.edu., Santos RO; Department of Biology, Florida International University, Miami, FL, USA., James WR; Earth and Environment Department, Florida International University, Miami, FL, USA; Department of Biology, Florida International University, Miami, FL, USA., Rezek R; Department of Marine Science, Coastal Carolina University, Conway, SC, USA., Cerveny D; Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden; Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Vodňany, Czech Republic., Boucek RE; Bonefish and Tarpon Trust, Miami, FL, USA., Adams AJ; Bonefish and Tarpon Trust, Miami, FL, USA; Florida Atlantic University Harbor Branch Oceanographic Institute, Fort Pierce, FL, USA., Fick J; Department of Chemistry, Umeå University, Umeå, Sweden., Brodin T; Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden., Rehage JS; Earth and Environment Department, Florida International University, Miami, FL, USA.
Jazyk: angličtina
Zdroj: Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2024 Oct; Vol. 275, pp. 107064. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1016/j.aquatox.2024.107064
Abstrakt: To date, the presence of pharmaceuticals has been extensively documented across a wide range of aquatic systems and biota. Further, substantial progress has been made in transitioning from laboratory assessments of pharmaceutical fate and effects in fish to in situ assessments of exposure and effects; however, certain research areas remain understudied. Among these is investigation of differential accumulation across multiple internal tissues in wild marine fish beyond the species commonly sampled in laboratory and freshwater field settings. This study examined the presence of pharmaceuticals across four tissues (plasma, muscle, brain, and liver) in a wild marine fish, bonefish (Albula vulpes), throughout coastal South Florida, USA. Differential accumulation across tissues was assessed for the number and concentration, identity, and composition of accumulated pharmaceuticals by sampling 25 bonefish and analyzing them for 91 pharmaceuticals. The concentration of pharmaceuticals was highest in plasma > liver > brain > muscle, while the number of pharmaceuticals was highest in liver > brain > plasma > muscle. The identity of detected pharmaceuticals was tissue specific, and there was an inverse relationship between the number of detections for each pharmaceutical and its log K ow . The composition of pharmaceuticals was tissue specific for both pharmaceutical presence/absence and concentration. Across all tissues, the greatest similarity was between brain and liver, which were more similar to plasma than to muscle, and muscle was the most distinct tissue. For tissue compositional variability, muscle was the most diverse in accumulated pharmaceuticals, while plasma, brain, and liver were similarly variable. With the highest concentrations in plasma and highest number in liver, and documented variability in accumulated pharmaceuticals across tissues, our results highlight the importance of tissue selection when surveying exposure in wild fish, suggesting that multi-tissue analysis would allow for a more comprehensive assessment of exposure diversity and risk of adverse effects.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: