Corrosion behavior, antibacterial properties and in vitro and in vivo biocompatibility of biodegradable Zn-5Cu-xMg alloy for bone-implant applications.

Autor: Su L; School of Materials Science and Engineering, Central South University, Changsha 410083, China., Liu W; Department of Orthopaedics, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410008, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Changsha, China., Wang Y; School of Materials Science and Engineering, Central South University, Changsha 410083, China., Jiang Y; School of Materials Science and Engineering, Central South University, Changsha 410083, China; State Key Lab for Powder Metallurgy, Central South University, Changsha 410083, China. Electronic address: jybin8113@163.com., Li Z; School of Materials Science and Engineering, Central South University, Changsha 410083, China; State Key Lab for Powder Metallurgy, Central South University, Changsha 410083, China., Wang M; School of Materials Science and Engineering, Central South University, Changsha 410083, China., Liu G; Department of Orthopaedics, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410008, China. Electronic address: 215202792@qq.com.
Jazyk: angličtina
Zdroj: Biomaterials advances [Biomater Adv] 2024 Dec; Vol. 165, pp. 214000. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1016/j.bioadv.2024.214000
Abstrakt: Reasonable optimization of degradation rate, antibacterial performance and biocompatibility is crucial for the development of biodegradable zinc alloy medical implant devices with antibacterial properties. In this study, various amounts of Mg elements were incorporated into Zn5Cu alloy to modulate the degradation rate, antibacterial properties and biocompatibility. The effects of Mg contents on the microstructure, corrosion behavior, antibacterial properties and biocompatibility of Zn-5Cu-xMg alloy were extensively investigated. The results revealed that with an increase of Mg content, the amount of Mg 2 Zn 11 phase increased and its galvanic effect with the Zn matrix was enhanced, which accelerated the corrosion process and led to higher corrosion rate and high degradation rate of the alloy. Additionally, there was an increased release of Mg 2+ and Zn 2+ ions from the alloy which imparted excellent resistance against Escherichia coli and Staphylococcus aureus bacteria and improved biocompatibility, subcutaneous antibacterial and immune microenvironment regulation properties. Zn-5Cu-2 Mg exhibited superior antibacterial ability, cell compatibility, proliferation effect, subcutaneous antibacterial and immune microenvironment regulation performances, which can work as a promising candidate of biodegradable antibacterial medical implants.
Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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