Higher Striatal Dopamine is Related With Lower Physical Performance Fatigability in Community-Dwelling Older Adults.

Autor:	Rosano C; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Chahine LM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gay EL; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Coen PM; AdventHealth Research Institute, Orlando, Florida, USA., Bohnen NI; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Studenski SA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., LoPresti B; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rosso AL; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Huppert T; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Newman AB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Royse SK; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kritchevsky SB; Gerontology and Geriatric Medicine, Wake Forest University, Winston-Salem, North Carolina, USA., Glynn NW; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 Nov 01; Vol. 79 (11).
DOI:	10.1093/gerona/glae209
Abstrakt:	Background: Fatigability in community-dwelling older adults is highly prevalent and disabling, but lacks a treatment. Greater nigrostriatal dopaminergic signaling can ameliorate performance fatigability in healthy young adults, but its role in community-dwelling older adults is not known. We hypothesized that higher nigrostriatal dopaminergic integrity would be associated with lower performance fatigability, independent of cardiopulmonary and musculoskeletal energetics and other health conditions. Methods: In 125 older adults participating in the Study of Muscle, Mobility and Aging, performance fatigability was measured as performance deterioration during a fast 400 m walk (% slowing down from the 2nd to the 9th lap). Nigrostriatal DA integrity was measured using (+)-[11C] dihydrotetrabenazine (DTBZ) PET imaging. The binding signal was obtained separately for the subregions regulating sensorimotor (posterior putamen), reward (ventral striatum), and executive control processes (dorsal striatum). Multivariable linear regression models of performance fatigability (dependent variable) estimated the coefficients of dopamine integrity in striatal subregions, adjusted for demographics, comorbidities, and cognition. Models were further adjusted for skeletal muscle energetics (via biopsy) and cardiopulmonary fitness (via cardiopulmonary exercise testing). Results: Higher [11C]-DTBZ binding in the posterior putamen was significantly associated with lower performance fatigability (demographic-adjusted standardized β = -1.08, 95% CI: -1.96, -0.20); results remained independent of adjustment for other covariates, including cardiopulmonary and musculoskeletal energetics. Associations with other striatal subregions were not significant. Discussion: Dopaminergic integrity in the sensorimotor striatum may influence performance fatigability in older adults without clinically overt diseases, independent of other aging systems. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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