COVID-19 IgG seropositivity and its determinants in occupational groups of varying infection risks in two Andean cities of Ecuador before mass vaccination.

Autor: Leon-Rojas JE; Departamento de Pediatría, Obstetricia y Ginecología y Medicina Preventiva, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain.; Research Network Grups de Recerca d'Amèrica i Àfrica Llatines (GRAAL), Universidad Internacional del Ecuador, Quito, Ecuador., Arias-Erazo F; School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador.; Grupo de Investigación en Sanidad Animal y Humana (GISAH) ESPE, Quito, Ecuador., Jiménez-Arias P; Research Network Grups de Recerca d'Amèrica i Àfrica Llatines (GRAAL), Universidad Internacional del Ecuador, Quito, Ecuador.; Grupo de Investigación en Sanidad Animal y Humana (GISAH) ESPE, Quito, Ecuador.; Departamento de Ciencias de la Vida y de la Agricultura, Universidad de las Fuerzas Armadas ESPE, Sangolquí, Ecuador., Recalde-Navarrete R; Research Network Grups de Recerca d'Amèrica i Àfrica Llatines (GRAAL), Universidad Internacional del Ecuador, Quito, Ecuador.; Medical School, Universidad Tecnica de Ambato, Ambato, Ecuador., Guevara A; Universidad Central del Ecuador, Quito, Ecuador., Coloma J; School of Public Health, University of California, Berkeley, Berkeley, CA, United States of America., Martin M; Departamento de Pediatría, Obstetricia y Ginecología y Medicina Preventiva, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain.; Research Network Grups de Recerca d'Amèrica i Àfrica Llatines (GRAAL), Universidad Internacional del Ecuador, Quito, Ecuador.; School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador., Chis Ster I; Institute of Infection and Immunity, St George's University of London, London, United Kingdom., Cooper P; School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador.; Institute of Infection and Immunity, St George's University of London, London, United Kingdom., Romero-Sandoval N; Research Network Grups de Recerca d'Amèrica i Àfrica Llatines (GRAAL), Universidad Internacional del Ecuador, Quito, Ecuador.; School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Aug 29; Vol. 19 (8), pp. e0309466. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0309466
Abstrakt: Background: The COVID-19 pandemic has caused over 68.7 million infections and 1.35 million deaths in South America. There are limited data on SARS-CoV-2 seropositivity and its determinants from Andean countries prior to mass vaccinations against COVID-19.
Objective: To estimate SARS-CoV-2 seropositivity and its determinants before vaccination in occupational groups of adults presumed to have different levels of exposure and associations with potential symptomatology.
Methods: We measured seropositivity of anti-SARS-CoV-2 IgG antibodies in a cross-sectional study of vaccine-naïve adults aged 18 years and older, recruited within three occupational risk groups (defined as low [LR], moderate [MR], and high [HR]) between January and September 2021 in two Andean cities in Ecuador. Associations with risk factors were estimated using logistic regression.
Results: In a sample of 882 adults, IgG seropositivity for the three different occupational risk groups was 39.9% (CI 95% 35.3-44.6), 74.6% (CI 95% 66.4-81.4), and 39.0% (CI 95% 34.0-44.4) for the HR, MR, and LR groups, respectively. History of an illness with loss of taste and/or smell was significantly associated with seropositivity in all occupational groups, with adjusted ORs of 14.31 (95%CI, 5.83-35.12; p<0.001), 14.34 (95%CI 3.01-68.42; p<0.001), and 8.79 (95%CI 2.69-28.72; p<0.001), for the HR, MR, and LR groups, respectively; while fever was significant for the LR group with an adjusted OR of 1.24 (95%CI, 1.11-4.57; p = 0.025) and myalgia for the HR group with an adjusted OR of 2.07 (95%CI, 1.13-3.81; p = 0.019).
Conclusion: Notable proportions of seropositivity were seen in all occupational groups between January and September 2021 prior to mass vaccination. Loss of taste and/or smell was strongly associated with presence of anti-SARS-CoV-2 IgG antibodies irrespective of presumed occupational exposure risk.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Leon-Rojas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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