Prostate Cancer Disparities in Clinical Characteristics and Survival among Black and Latino Patients Considering Nativity: Findings from the California Cancer Registry.

Autor:	Freedland AR; Department of Epidemiology and Biostatistics, Program in Public Health, University of California, Irvine, Irvine, California., Sanchez Mendez J; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California., Liu L; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Los Angeles Cancer Surveillance Program, University of Southern California, Los Angeles, California.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California., Hamilton AS; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Los Angeles Cancer Surveillance Program, University of Southern California, Los Angeles, California.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California., Zhang J; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Los Angeles Cancer Surveillance Program, University of Southern California, Los Angeles, California., Hwang AE; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Los Angeles Cancer Surveillance Program, University of Southern California, Los Angeles, California., Ballas L; Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California., Abreu AL; Department of Urology, Keck School of Medicine, Los Angeles, California., Deapen D; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Los Angeles Cancer Surveillance Program, University of Southern California, Los Angeles, California.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California., Stern MC; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.; Department of Urology, Keck School of Medicine, Los Angeles, California.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 Nov 01; Vol. 33 (11), pp. 1512-1522.
DOI:	10.1158/1055-9965.EPI-24-0678
Abstrakt:	Background: We investigated clinical characteristics and prostate cancer survival patterns among Latino patients considering nativity compared with non-Latino Black (NLB) and non-Latino White (NLW) patients. Methods: We used data from the California Cancer Registry (1995-2021), which included 347,540 NLW, 50,032 NLB, and 75,238 Latino patients with prostate cancer. Frequencies of sociodemographic and clinical variables were assessed using χ2 tests. Multivariable regression models were fitted to evaluate determinants of treatment reception, Gleason upgrade, and survival differences. Exploratory analyses were conducted grouping Latino cases into US born and non-US born by country of origin. Results: Compared with NLW, NLB cases had the greatest proportion of younger patients, whereas non-US-born Latino patients had the greatest proportion of low socioeconomic status and uninsured patients. Non-US-born Latinos showed a greater proportion of diagnoses completed with <6 core biopsies, Gleason >8, stage IV tumors, and metastasis. Multivariable analyses showed that compared with NLW, Latino patients were as likely to receive treatment, whereas NLB cases were less likely (OR = 0.81; 95% confidence interval, 0.67-0.98; P = 0.029). Compared with NLW, non-US-born Latino cases were less likely to die of prostate cancer (HR = 0.78; 95% confidence interval, 0.64-0.94; P = 0.011), with no difference reported for NLB cases. Conclusions: Considering sociodemographic and clinical characteristics, non-US-born Latino patients with prostate cancer had better survival than NLW. This highlights the need to identify key determinants of these survival differences and the importance of sociodemographic and clinical determinants in survival disparities. Impact: Our study emphasizes the importance of considering nativity among Latino patients to understand prostate cancer disparities and outcomes in this population. (©2024 American Association for Cancer Research.)
Databáze:	MEDLINE
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