Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.

Autor:	Elum JE; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA., Szelenyi ER; Department of Biological Structure, University of Washington, Seattle, WA, USA; University of Washington Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), Seattle, WA, USA., Juarez B; Department of Neurobiology, University of Maryland, Baltimore, MD, USA., Murry AD; Department of Biological Structure, University of Washington, Seattle, WA, USA., Loginov G; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Zamorano CA; Department of Pharmacology, University of Washington, Seattle, WA, USA; University of Washington Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), Seattle, WA, USA., Gao P; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA, USA., Wu G; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA, USA., Ng-Evans S; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA., Yee JX; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Xu X; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA, USA., Golden SA; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA; Department of Biological Structure, University of Washington, Seattle, WA, USA; University of Washington Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), Seattle, WA, USA., Zweifel LS; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA; University of Washington Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), Seattle, WA, USA. Electronic address: larryz@uw.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114668. Date of Electronic Publication: 2024 Aug 27.
DOI:	10.1016/j.celrep.2024.114668
Abstrakt:	Ventral tegmental area (VTA) dopamine neurons regulate reward-related associative learning and reward-driven motivated behaviors, but how these processes are coordinated by distinct VTA neuronal subpopulations remains unresolved. Here, we compare the contribution of two primarily dopaminergic and largely non-overlapping VTA subpopulations, all VTA dopamine neurons and VTA GABAergic neurons of the mouse midbrain, to these processes. We find that the dopamine subpopulation that projects to the nucleus accumbens (NAc) core preferentially encodes reward-predictive cues and prediction errors. In contrast, the subpopulation that projects to the NAc shell preferentially encodes goal-directed actions and relative reward anticipation. VTA GABA neuron activity strongly contrasts VTA dopamine population activity and preferentially encodes reward outcome and retrieval. Electrophysiology, targeted optogenetics, and whole-brain input mapping reveal multiple convergent sources that contribute to the heterogeneity among VTA dopamine subpopulations that likely underlies their distinct encoding of reward-related associations and motivation that defines their functions in these contexts. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu