Microglia and Multiple Sclerosis.
| Autor: | Hammond BP; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada., Panda SP; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada., Kaushik DK; Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada., Plemel JR; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada. jrplemel@ualberta.ca.; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada. jrplemel@ualberta.ca.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada. jrplemel@ualberta.ca.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada. jrplemel@ualberta.ca. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in neurobiology [Adv Neurobiol] 2024; Vol. 37, pp. 445-456. |
| DOI: | 10.1007/978-3-031-55529-9_25 |
| Abstrakt: | Multiple sclerosis (MS) is a devastating autoimmune disease that leads to profound disability. This disability arises from the stochastic, regional loss of myelin-the insulating sheath surrounding neurons-in the central nervous system (CNS). The demyelinated regions are dominated by the brain's resident macrophages: microglia. Microglia perform a variety of functions in MS and are thought to initiate and perpetuate demyelination through their interactions with peripheral immune cells that traffic into the brain. However, microglia are also likely essential for recruiting and promoting the differentiation of cells that can restore lost myelin in a process known as remyelination. Given these seemingly opposing functions, an overarching beneficial or detrimental role is yet to be ascribed to these immune cells. In this chapter, we will discuss microglia dynamics throughout the MS disease course and probe the apparent dichotomy of microglia as the drivers of both demyelination and remyelination. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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