Current state of proton therapy for tumors of the central nervous system in Spain: physical bases, indications, controversies and perspectives.

Autor: Corrales-García EM; Servicio Oncología Radioterápica, Hospital Universitario de Burgos, Burgos, Spain., Aristu-Mendioroz JJ; Unidad de Terapia de Protones, Clínica Universitaria de Navarra, Madrid, Spain., Castro-Novais J; Servicio de Radiofísica y Protección Radiológica, Centro de Protonterapia. Hospital Universitario Quironsalud, Madrid, Spain., Matute-Martín R; Servicio Oncología Radioterápica, Centro de Protonterapia, Hospital Quironsalud, Madrid, Spain., Learra-Martínez MC; Comisión de Protonterapia de La Comunidad de Castilla y LeónServicio de Atención Hospitalaria y CoordinaciónDirección Técnica de Asistencia SanitariaDirección General de Asistencia Sanitaria y HumanizaciónGerencia Regional de Salud de Castilla y León, Valladolid, Spain., Delgado-López PD; Servicio de Neurocirugía, Hospital Universitario de Burgos, Avda Islas Baleares 3, 09006, Burgos, Spain. pedrodl@yahoo.com.
Jazyk: angličtina
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2024 Aug 29. Date of Electronic Publication: 2024 Aug 29.
DOI: 10.1007/s12094-024-03624-z
Abstrakt: The unique biophysical properties of proton therapy (PT), regarding the precise dose distribution, a remarkable better sparing of surrounding normal tissues, and the decreasing costs have promoted the spread of this technique worldwide. In Spain, eleven new PT centers, added to the currently two in function, are expected to be available in the near future. Indications for PT are currently evolving. The suitability of PT in central nervous system tumors of the adult population has been extrapolated from the favorable experience in children and adolescents. Given the lack of appropriate randomized trials, controversies remain regarding its use in lower grade tumors, re-irradiation, and other clinical scenarios in which an a priori dose distribution benefit is expected compared to photon-based radiotherapy. PT is a reasonable option in many brain and spinal tumors associating long life expectancy, in which cognitive decline, and the appearance of radiation-induced neoplasms can be minimized.Estado actual de la terapia con protones en los tumores del sistema nervioso central en España: bases físicas, indicaciones, controversias y perspectivas.
(© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)
Databáze: MEDLINE
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