Cross-talk between immune cells and tumor cells in non-Hodgkin lymphomas arising in common variable immunodeficiency.

Autor:	Sharma S; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Goyal T; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Chawla S; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Nadig PL; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Bhodiakhera A; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Jindal AK; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Pilania RK; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Dhaliwal M; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Rawat A; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India., Singh S; Department of Pediatrics (Allergy & Immunology Unit), Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India.
Jazyk:	angličtina
Zdroj:	Expert review of clinical immunology [Expert Rev Clin Immunol] 2024 Dec; Vol. 20 (12), pp. 1461-1470. Date of Electronic Publication: 2024 Sep 04.
DOI:	10.1080/1744666X.2024.2398546
Abstrakt:	Introduction: CVID is the commonest and most symptomatic primary immune deficiency of adulthood. NHLs are the most prevalent malignancies in CVID. The cross-talk between tumor cells and immune cells may be an important risk factor in lymphomagenesis. Areas Covered: The present review highlights immune cell, genetic and histopathological alterations in the CVID-associated NHLs. Expert Opinion: CVID patients exhibit some notable immune defects that may predispose to lymphomas. T/NK cell defects including reduced T cells, naïve CD4+T cells, T regs, and Th17 cells, increased CD8+T cells with reduced T cell proliferative and cytokine responses and reduced iNKT and NK cell count and cytotoxicity. B cell defects include increased transitional and CD21 low B cells, clonal IgH gene rearrangements, and increased BCMA levels. Increase in IL-9, sCD30 levels, and upregulation of BAFF-BAFFR signaling are associated with lymphomas in CVID. Increased expression of PFTK1 , duplication of ORC4L , germline defects in TACI , NFKB1 , and PIK3CD , and somatic mutations in NOTCH2 and MYD88 are reported in CVID-associated lymphomas. Upregulation of PD-L1-PD-1 pathway may also promote lymphomagenesis in CVID. These abnormalities need to be explored as prognostic or predictive markers of CVID-associated NHLs by large multicentric studies.
Databáze:	MEDLINE
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