Bacterial Insights: Unraveling the Ocular Microbiome in Glaucoma Pathogenesis.

Autor:	Gagliano C; Department of Medicine and Surgery, University of Enna 'Kore', 94100 Enna, Italy.; Eye Clinic, Catania University San Marco Hospital, 95121 Catania, Italy., Salvetat ML; Department of Ophthalmology, Azienda Sanitaria Friuli Occidentale, 33170 Pordenone, Italy., Musa M; Department of Optometry, University of Benin, 300238 Benin, Edo, Nigeria., D'Esposito F; Imperial College Ophthalmic Research Group (ICORG) Unit, Imperial College, NW15QH London, UK.; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Napoli, Italy., Rusciano D; Fidia Ophthalmics, 95125 Catania, Italy., Maniaci A; Department of Medicine and Surgery, University of Enna 'Kore', 94100 Enna, Italy., Pellegrini F; Department of Ophthalmology, Azienda Sanitaria Friuli Occidentale, 33170 Pordenone, Italy., Scibilia G; Department of Obstetrics and Gynecology, 'Giovanni Paolo II' Hospital, 97100 Ragusa, Italy., Zeppieri M; Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Aug 23; Vol. 29 (8), pp. 310.
DOI:	10.31083/j.fbl2908310
Abstrakt:	This review explores the connection between the ocular surface microbiome and glaucoma, highlighting its impact on disease progression. Beginning with an overview of global glaucoma significance, it emphasizes the importance of understanding the cellular characteristics and microbiology of the ocular microbiome. A search was conducted on the PubMed and Cochrane Library databases using the phrase "ocular microbiome glaucoma". 0 records were returned from the Cochrane Library while 21 were returned from PubMed. A total of 21 results were retrieved from 2017 to 2024. This comprised one opinion paper, four original research articles, and 16 reviews. This review covered the anatomy of the ocular surface, advanced analysis methods, and the ocular microbiome. It also delved into dysbiosis in glaucoma, addressing altered microbial communities and their potential role in disease progression. The intricate interplay between the ocular microbiome and the host's immune system is explored, emphasizing crosstalk and inflammatory responses. The review concludes by discussing therapeutic implications, including modulating ocular microbiota and potential future treatment strategies. Understanding the microbiome in healthy and glaucomatous eyes can help researchers and clinicians in innovative approaches to ocular health. Competing Interests: The authors declare no conflict of interest. Dario Rusciano worked for Fidia Ophthalmics before retirement and declares no conflict of interest. Given his role as Guest Editor and Editorial Board member, Dario Rusciano had no involvement in the peer-review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Adrian Gericke. (© 2024 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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