Clonal Hematopoiesis Is Associated With Long-Term Adverse Outcomes Following Cardiac Surgery.

Autor: Ninni S; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France.; Department of Medicine and Research Center Montreal Heart Institute and Université de Montréal Montreal Canada., Vicario R; Immunology Program Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center New York NY USA., Coisne A; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Woitrain E; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Tazibet A; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Stewart CM; Division of Solid Tumor Oncology, Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA., Diaz LA Jr; Division of Solid Tumor Oncology, Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA., White JR; Resphera Biosciences Baltimore MD USA., Koussa M; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Dubrulle H; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Juthier F; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Jungling M; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Vincentelli A; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Edme JL; Université de Lille, EA 4483, IMPECS: IMPact of Environmental ChemicalS on Human Health, CHU Lille Lille France., Nattel S; Department of Medicine and Research Center Montreal Heart Institute and Université de Montréal Montreal Canada., de Winther M; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity Amsterdam University Medical Centers Amsterdam The Netherlands., Geissmann F; Immunology Program Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center New York NY USA., Dombrowicz D; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Staels B; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France., Montaigne D; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID Lille France.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2024 Sep 03; Vol. 13 (17), pp. e034255. Date of Electronic Publication: 2024 Aug 29.
DOI: 10.1161/JAHA.123.034255
Abstrakt: Background: Cardiac surgery triggers sterile innate immune responses leading to postoperative complications. Clonal hematopoiesis (CH) is associated with short-term inflammation-mediated outcomes after cardiac surgery. The impact of CH on long-term postoperative outcomes remains unknown.
Methods and Results: In this cohort study, patients undergoing elective cardiac surgery were included from January 2017 to September 2019. Patients were screened for CH using a predefined gene panel of 19 genes. Recorded clinical events were all-cause death, major adverse cardiac and cerebral events including cardiovascular death, myocardial infarction or nonscheduled coronary revascularization, stroke, and hospitalization for acute heart failure. The primary study outcome was time to a composite criterion including all-cause mortality and major adverse cardiac and cerebral events. Among 314 genotyped patients (median age: 67 years; interquartile range 59-74 years), 139 (44%) presented with CH, based on a variant allelic frequency ≥1%. Carriers of CH had a higher proportion of patients with a history of atrial fibrillation (26% for CH versus 17% for non-CH carriers, P =0.022). The most frequently mutated genes were DNMT3A , TET2 , and ASXL1 . After a median follow-up of 1203 [813-1435] days, the primary outcome occurred in 50 patients. After multivariable adjustment, CH was independently associated with a higher risk for the primary outcome (hazard ratio, 1.88 [95% CI, 1.05-3.41], P =0.035). Most adverse events occurred in patients carrying TET2 variants.
Conclusions: In patients undergoing cardiac surgery, CH is frequent and associated with a 2-fold increased long-term risk for major adverse clinical outcomes. CH is a novel risk factor for long-term postcardiac surgery complications and might be useful to personalize management decisions.
Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03376165.
Databáze: MEDLINE
Externí odkaz: