Thalamic volume in very preterm infants: associations with severe brain injury and neurodevelopmental outcome at two years.

Autor:	Trimarco E; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain., Jafrasteh B; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain., Jiménez-Luque N; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain., Marín Almagro Y; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain., Román Ruiz M; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain., Lubián Gutiérrez M; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.; Division of Neonatology, Department of Paediatrics, Puerta del Mar University Hospital, Cádiz, Spain., Ruiz González E; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.; Division of Neonatology, Department of Paediatrics, Puerta del Mar University Hospital, Cádiz, Spain., Segado Arenas A; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.; Division of Neonatology, Department of Paediatrics, Puerta del Mar University Hospital, Cádiz, Spain., Lubián-López SP; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.; Division of Neonatology, Department of Paediatrics, Puerta del Mar University Hospital, Cádiz, Spain., Benavente-Fernández I; Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.; Division of Neonatology, Department of Paediatrics, Puerta del Mar University Hospital, Cádiz, Spain.; Area of Paediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2024 Aug 14; Vol. 15, pp. 1427273. Date of Electronic Publication: 2024 Aug 14 (Print Publication: 2024).
DOI:	10.3389/fneur.2024.1427273
Abstrakt:	Introduction: Several studies demonstrate the relationship between preterm birth and a reduced thalamus volume at term-equivalent age. In contrast, this study aims to investigate the link between the thalamic growth trajectory during the early postnatal period and neurodevelopment at two years of age. Methods: Thalamic volume was extracted from 84 early MRI scans at postmenstrual age of 32.33 (± 2.63) weeks and 93 term-equivalent age MRI scans at postmenstrual age of 42.05 (± 3.33) weeks of 116 very preterm infants (56% male) with gestational age at birth of 29.32 (± 2.28) weeks and a birth weight of 1158.92 (± 348.59) grams. Cognitive, motor, and language outcomes at two years of age were assessed with Bayley Scales of Infant and Toddler Development Third Edition. Bivariate analysis was used to describe the clinical variables according to neurodevelopmental outcomes and multilevel linear regression models were used to examine the impact of these variables on thalamic volume and its relationship with neurodevelopmental outcomes. Results: The results suggest an association between severe brain injury and thalamic growth trajectory (β coef = -0.611; p < 0.001). Moreover, thalamic growth trajectory during early postnatal life was associated with the three subscale scores of the neurodevelopmental assessment (cognitive: β coef = 6.297; p = 0.004; motor: β coef = 7.283; p = 0.001; language: β coeficient = 9.053; p = 0.002). Discussion: These findings highlight (i) the impact of severe brain injury on thalamic growth trajectory during early extrauterine life after preterm birth and (ii) the relationship of thalamic growth trajectory with cognitive, motor, and language outcomes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Trimarco, Jafrasteh, Jiménez-Luque, Marín Almagro, Román Ruiz, Lubián Gutiérrez, Ruiz González, Segado Arenas, Lubián-López and Benavente-Fernández.)
Databáze:	MEDLINE
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