Incidence, Nature and Natural History of Additional Histological Findings in Preimplantation and Implantation Kidney Transplant Biopsies.

Autor:	Paterson AL; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Broecker V; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden., Gray M; Department of Transplant Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Chalisey A; Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Pettigrew GJ; Department of Surgery, University of Cambridge, Cambridge, United Kingdom., Summers DM; Department of Transplant Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2024 Aug 14; Vol. 37, pp. 12997. Date of Electronic Publication: 2024 Aug 14 (Print Publication: 2024).
DOI:	10.3389/ti.2024.12997
Abstrakt:	The quality assurance provided by preimplantation biopsy quantification of chronic damage may allow greater use of kidneys from expanded criteria donors, and thereby expand the deceased donor pool. Preimplantation biopsy may, however, identify additional acute or chronic pathologies not considered in the scoring of chronic damage, and these may influence the decision to implant or discard the kidney. This single-centre retrospective cohort study of a contemporary UK donor population systematically characterised the nature of additional findings in 1,046 preimplantation and implantation biopsies over an eight-year period. A diverse range of findings were identified in 111/1,046 (11%) organs; most frequently diabetic glomerulopathy, focal segmental glomerulosclerosis, (micro)thrombi, neutrophil casts, and immunoglobulin/complement staining. Seventy (63%) of these were transplanted, with subsequent biopsy in 41 (58%) cases confirming that 80% of the initial acute changes had spontaneously resolved, while there was no progression of diabetic glomerulopathy, and the lesions of focal segmental glomerulosclerosis were not identified. Over 75% of assessable grafts with additional histological findings at the time of transplant showed adequate function at one-year following transplant. In conclusion, most histological abnormalities that may be identified in addition to chronic scarring in preimplantation kidney biopsies would not preclude transplantation nor predict poor graft function. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Paterson, Broecker, Gray, Chalisey, Pettigrew and Summers.)
Databáze:	MEDLINE
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