Renin-Angiotensin System Genes Polymorphisms in Patients With COVID-19 and Its Relation to Severe Cases of SARS-CoV-2 Infection.

Autor: Bragina AE; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; World-Class Research Center 'Digital biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia., Tarzimanova AI; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Rodionova YN; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; World-Class Research Center 'Digital biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia., Ogibenina ES; University Clinical Hospital #4, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Suvorov AY; World-Class Research Center 'Digital biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia., Druzhinina NA; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; World-Class Research Center 'Digital biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia., Vasilyeva LV; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Ishina TI; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Medvedev ID; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Borlakova MS; Department of Pharmacology, Institute of Digital Biodesign and Modeling of Living Systems, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Komelkova AR; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Gushchina DV; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Khachaturov AA; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Podzolkov VI; 2nd Internal Medicine (2nd Faculty Therapy) Department, N.V. Sklifosovskiy Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Jazyk: angličtina
Zdroj: Journal of clinical medicine research [J Clin Med Res] 2024 Aug; Vol. 16 (7-8), pp. 355-362. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.14740/jocmr5223
Abstrakt: Background: Different variants of single nucleotide polymorphisms (SNPs) of angiotensinogen (AGT), angiotensin-converting enzyme type 1 (ACE1), and angiotensin II receptors type 1 (AGTR1) and 2 (AGTR2) genes determine different susceptibility to cardiovascular disease (CVD) and hypertension, which can be considered as risk factors for fatal outcomes among coronavirus disease 2019 (COVID-19) patients. The objective of our study was to assess the relation between the frequency of SNPs of the renin-angiotensin system (RAS) components, and the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: The cross-sectional study included 100 patients with a laboratory-confirmed diagnosis of COVID-19 admitted to the hospital. Criteria for severe COVID-19 included respiratory rate (RR) > 30/min, blood oxygen saturation (SpO 2 ) ≤ 93%, signs of unstable hemodynamics with systolic blood pressure (SBP) < 90 and/or diastolic blood pressure (DBP) < 60 mm Hg. All patients were identified with alleles and genotypes of the polymorphic markers rs4762 of the AGT gene, rs1799752 of the ACE1 gene, rs5186 of the AGTR1 gene and rs1403543 of the AGTR2 gene using the polymerase chain reaction method in human DNA preparations on real-time CFX96C1000 Touch, Bio-Rad equipment (Syntol, Russia). Statistical analysis was performed in R v.4.2.
Results: Patients were divided into groups with severe (n = 44) and moderate COVID-19 (n = 56). For ACE1 rs1799752, a significant deviation from the population distribution was detected in both studied subgroups. A higher frequency of the C allele SNP rs5186 AGTR1 gene was detected in the group with severe disease. More frequent A/A genotype of SNP rs1403543 AGTR2 was detected among females with severe COVID-19. Haplotype analysis revealed more common DCG haplotype among patients with severe COVID-19. The odds ratio for severe COVID-19 in the presence of the DCG haplotype was 3.996 (95% confidential interval: 1.080 -14.791, P < 0.05).
Conclusions: Our data suggest that the SNP genes of the RAS components, may allow to identify groups of patients predisposed to a more severe course of COVID-19.
Competing Interests: The authors confirm that there is no potential conflict of interest to disclose in relation to this article.
(Copyright 2024, Bragina et al.)
Databáze: MEDLINE
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