Presence of fetal microchimerisms in the heart and effect on cardiac repair.

Autor:	Llorente V; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., López-Olañeta M; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Blázquez-López E; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Servicio de Ap. Digestivo del HGU Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Vázquez-Ogando E; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Servicio de Ap. Digestivo del HGU Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Martínez-García M; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Vaquero J; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Servicio de Ap. Digestivo del HGU Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain., Carmona S; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Desco M; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Departamento de Bioingeniería, Universidad Carlos III de Madrid, Leganés, Spain., Lara-Pezzi E; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Gómez-Gaviro MV; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Departamento de Bioingeniería, Universidad Carlos III de Madrid, Leganés, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Aug 05; Vol. 12, pp. 1390533. Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).
DOI:	10.3389/fcell.2024.1390533
Abstrakt:	Multiple complex biological processes take place during pregnancy, including the migration of fetal cells to maternal circulation and their subsequent engraftment in maternal tissues, where they form microchimerisms. Fetal microchimerisms have been identified in several tissues; nevertheless, their functional role remains largely unknown. Different reports suggest these cells contribute to tissue repair and modulate the immune response, but they have also been associated with pre-eclampsia and tumor formation. In the maternal heart, cells of fetal origin can contribute to different cell lineages after myocardial infarction. However, the functional role of these cells and their effect on cardiac function and repair are unknown. In this work, we found that microchimerisms of fetal origin are present in the maternal circulation and graft in the heart. To determine their functional role, WT female mice were crossed with male mice expressing the diphtheria toxin (DT) receptor. Mothers were treated with DT to eliminate microchimerisms and the response to myocardial infarction was investigated. We found that removal of microchimerisms improved cardiac contraction in postpartum and post-infarction model females compared to untreated mice, where DT administration had no significant effects. These results suggest that microchimerisms play a detrimental role in the mother following myocardial infarction. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Llorente, López-Olañeta, Blázquez-López, Vázquez-Ogando, Martínez-García, Vaquero, Carmona, Desco, Lara-Pezzi and Gómez-Gaviro.)
Databáze:	MEDLINE
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