| Autor: |
Ancuţa DL; Cantacuzino National Medical Military Institute for Research and Development, 050096 Bucharest, Romania.; Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 050097 Bucharest, Romania., Alexandru DM; Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 050097 Bucharest, Romania., Ţucureanu C; Cantacuzino National Medical Military Institute for Research and Development, 050096 Bucharest, Romania., Coman C; Cantacuzino National Medical Military Institute for Research and Development, 050096 Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328 Bucharest, Romania. |
| Jazyk: |
angličtina |
| Zdroj: |
Microorganisms [Microorganisms] 2024 Jul 27; Vol. 12 (8). Date of Electronic Publication: 2024 Jul 27. |
| DOI: |
10.3390/microorganisms12081537 |
| Abstrakt: |
Peri-implantitis (PI) is a current concern whose understanding and resolution are ongoing. We aimed to evaluate in vivo a new treatment with antibacterial properties, based on bacterial lysates obtained from the strains of Aggregatibacter actinomycetemcomitans , Streptococcus oralis , and Fusobacterium nucleatum. This research was conducted on 30 rats with PI which were divided into three groups and treated with antibiotic and anti-inflammatory (AAi) drugs, bacterial lysates (BLs), and saline (C), respectively. The monitoring period included the clinical and paraclinical examination where hematological, immunological, imaging, and histopathological analysis were performed. No particular clinical signs were observed, but the radiological examination showed the loss of all implants in group C, in contrast to group BL which had the highest survival rate of devices. White cells showed a decrease from the PI period, as did the immunological analysis. Only IL-6 showed an increase in the AAi and BL groups. Histopathologically, the C group presented a high degree of bone destruction, and in the BL group, many attenuated inflammatory phenomena appeared compared to the AAi animals. Bacterial lysates have similar effects to antibiotic-based therapeutic regimens for PI, and their future use may help to improve the current therapeutic management of the disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
