Antifungal Effect of Poly(methyl methacrylate) with Farnesol and Undecylenic Acid against Candida albicans Biofilm Formation.

Autor: Išljamović M; Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.; Department of Dental Health Care, Health Center Niš, 18000 Niš, Serbia., Bonvin D; Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Milojević M; Department of Pharmacy, Faculty of Medicine, University of Niš, Blvd. Dr Zoran Djindjić 81, 18000 Niš, Serbia., Stojanović S; Department of Oral Surgery, Faculty of Medicine, University in Niš, Blvd. Dr Zoran Djindjić 81, 18000 Niš, Serbia., Spasić M; The Niš Dental University Clinic, Blvd. Dr Zoran Djindjić 52, 18000 Niš, Serbia., Stojković B; Department of Preventive and Pediatric Dentistry, Faculty of Medicine, University of Niš, Blvd. Dr Zoran Djindjić 81, 18000 Niš, Serbia., Janošević P; Department of Orthodontics, Faculty of Medicine, University of Niš, Blvd. Dr Zoran Djindjić 81, 18000 Niš, Serbia., Otašević S; Department of Microbiology and Immunology, Faculty of Medicine, University of Niš, Blv. Dr Zoran Djindjić 81, 18000 Niš, Serbia.; Public Health Institute Niš, Blvd. Dr Zoran Djindjić 50, 18000 Niš, Serbia., Ebersold MM; Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2024 Aug 08; Vol. 17 (16). Date of Electronic Publication: 2024 Aug 08.
DOI: 10.3390/ma17163936
Abstrakt: The control of Candida albicans biofilm formation on dentures made of poly(methyl methacrylate) (PMMA) is an important challenge due to the high resistance to antifungal drugs. Interestingly, the natural compounds undecylenic acid (UDA) and farnesol (FAR) both prevent C. albicans biofilm formation and could have a synergetic effect. We therefore modified PMMA with a combination of UDA and FAR (UDA+FAR), aiming to obtain the antifungal PMMA_UDA+FAR composites. Equal concentrations of FAR and UDA were added to PMMA to reach 3%, 6%, and 9% in total of both compounds in composites. The physico-chemical properties of the composites were characterized by Fourier-transform infrared spectroscopy and water contact angle measurement. The antifungal activity of the composites was tested on both biofilm and planktonic cells with an XTT test 0 and 6 days after the composites' preparation. The effect of the UDA+FAR combination on C. albicans filamentation was studied in agar containing 0.0125% and 0.4% UDA+FAR after 24 h and 48 h of incubation. The results showed the presence of UDA and FAR on the composite and decreases in the water contact angle and metabolic activity of both the biofilm and planktonic cells at both time points at non-toxic UDA+FAR concentrations. Thus, the modification of PMMA with a combination of UDA+FAR reduces C. albicans biofilm formation on dentures and could be a promising anti- Candida strategy.
Databáze: MEDLINE
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