| Autor: |
Torrisi A; Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy., Cutroneo M; Department of Mathematics and Computer Sciences, Physical Sciences and Earth Sciences (MIFT), Messina University, 98166 Messina, Italy., Torrisi L; Department of Mathematics and Computer Sciences, Physical Sciences and Earth Sciences (MIFT), Messina University, 98166 Messina, Italy., Lavalle S; Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy., Forzina A; IBSA Institut Biochimique SA, CH-6912 Lugano, Switzerland., Pegreffi F; Department of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2024 Aug 08; Vol. 29 (16). Date of Electronic Publication: 2024 Aug 08. |
| DOI: |
10.3390/molecules29163762 |
| Abstrakt: |
Vitamin D3 is a crucial fat-soluble pro-hormone essential for bolstering bone health and fortifying immune responses within the human body. Orodispersible films (ODFs) serve as a noteworthy formulation strategically designed to enhance the rapid dissolution of vitamin D, thereby facilitating efficient absorption in patients. This innovative approach not only streamlines the assimilation process but also plays a pivotal role in optimizing patient compliance and therapeutic outcomes. The judicious utilization of such advancements underscores a paradigm shift in clinical strategies aimed at harnessing the full potential of vitamin D for improved patient well-being. This study aims to examine the vitamin D3 ODF structure using spectroscopic techniques to analyze interactions with excipients like mannitol. Fourier-transform infrared spectroscopy (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy were utilized to assess molecular composition, intermolecular bonding, and vitamin D3 stability. Understanding these interactions is essential for optimizing ODF formulation, ensuring stability, enhancing bioavailability, and facilitating efficient production. Furthermore, this study involves a translational approach to interpreting chemical properties to develop an administration protocol for ODFs, aiming to maximize absorption and minimize waste. In conclusion, understanding the characterized chemical properties is pivotal for translating them into effective self-administration modalities for Vitamin D films. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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