| Autor: |
Hellemans S; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium.; ENT, Head and Neck Surgery, Antwerp University Hospital, 2650 Edegem, Belgium., Van de Perck E; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium.; ENT, Head and Neck Surgery, Antwerp University Hospital, 2650 Edegem, Belgium., Van Loo D; ENT, Head and Neck Surgery, Antwerp University Hospital, 2650 Edegem, Belgium., Verbraecken J; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium.; Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, 2650 Edegem, Belgium.; Department of Pulmonology, Antwerp University Hospital, 2650 Edegem, Belgium., Sands SA; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Azarbarzin A; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Dieltjens M; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium.; ENT, Head and Neck Surgery, Antwerp University Hospital, 2650 Edegem, Belgium.; Special Dentistry Care, Antwerp University Hospital, 2650 Edegem, Belgium., Op De Beeck S; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium., Vroegop A; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium.; ENT, Head and Neck Surgery, Antwerp University Hospital, 2650 Edegem, Belgium., Vanderveken OM; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, 2610 Antwerp, Belgium.; ENT, Head and Neck Surgery, Antwerp University Hospital, 2650 Edegem, Belgium.; Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, 2650 Edegem, Belgium.; Special Dentistry Care, Antwerp University Hospital, 2650 Edegem, Belgium. |
| Abstrakt: |
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP). However, predicting surgical success remains challenging, partly due to the contribution of non-anatomical factors. Therefore, combined medical treatment with acetazolamide, known to stabilize respiratory drive, may lead to superior surgical results. This double-blind, parallel-group randomized controlled trial evaluates the efficacy of acetazolamide as an add-on therapy to BRP in OSA. A total of 26 patients with moderate to severe OSA undergoing BRP were randomized to receive either acetazolamide or placebo post-surgery for 16 weeks. The group who was treated with BRP in combination with acetazolamide showed a reduction in AHI of 69.4%, significantly surpassing the 32.7% reduction of the BRP + placebo group ( p < 0.01). The sleep apnea-specific hypoxic burden also decreased significantly in the group who was treated with BRP + acetazolamide ( p < 0.01), but not in the group receiving BRP + placebo ( p = 0.28). Based on these results, acetazolamide as an add-on therapy following BRP surgery shows promise in improving outcomes for OSA patients, addressing both anatomical and non-anatomical factors. |
